In vivo Antimalarial Activity of Andrographis Paniculata Tablets
In vivo Antimalarial Activity of Andrographis Paniculata Tablets
复制标题
穿心莲片的体内抗疟活性
DOI：
10.1016/j.proche.2014.12.012
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
A. Hafid
中科院分区：
文献类型：
--
作者：
A. Widyawaruyanti;Muhammad Asrory;Wiwied Ekasari;D. Setiawan;A. Radjaram;L. Tumewu;A. Hafid
开发了三种含有二萜内酯作为活性物质的穿心莲提取物（AP 提取物 A 和 B）的植物药物产品，并检查了它们对伯氏疟原虫的抗疟活性。给伯格海氏菌感染的小鼠口服AP级分产品，每天两次，连续四天，即片剂I：AP级分A的湿颗粒配方；片剂II：AP级分B的湿颗粒配方；表三：AP组分B的固体分散体配方。结果显示，三种植物药产品均抑制了寄生虫的生长，抑制范围为70.15%至80.35%。片II、片III的抗疟活性无显着差异，片I与片II、片III的抗疟活性存在显着性差异。由此可见，抗疟活性取决于A的原料剂型。圆锥活性物质。
The formulation of three phytopharmaceutical products ofAndrographispaniculatafractions (AP fraction A and B) containing diterpene lactones as an active substance were developed and their antimalarial activities againstPlasmodium bergheihas been examined.In vivoantimalarial assay onP. bergheiinfected mice was carried out by oral administration,twice a dayfor four consecutive days of the AP fractions product, which were Tablet I: wet granulated formula of AP fraction A; Tablet II: wet granulated formula of AP fraction B; Tablet III: solid dispersion formula of AP fraction B.. The results revealed that three phytopharmaceutical products ofA.paniculatawere inhibited parasite's growth with inhibition range of 70.15% to 80.35%. There was no significant difference of antimalarial activities between Tablet II and III, meanwhile there was significant difference among Tablet I with Tablet II and Tablet III.It was concluded that antimalarial activity depending on raw material form ofA. paniculataactive substance.