A potential association between obesity and reduced effectiveness of COVID-19 vaccine-induced neutralizing humoral immunity
A potential association between obesity and reduced effectiveness of COVID-19 vaccine-induced neutralizing humoral immunity
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DOI：
10.1002/jmv.28130
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发表时间：
2022-09-14
影响因子：
12.7
通讯作者：
Azhar, Esam, I
中科院分区：
文献类型：
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作者：
Faizo, Arwa A.;Qashqari, Fadi S.;Azhar, Esam, I
由于肥胖对宿主免疫力的不利影响，本研究调查了COVID-19疫苗（BNT 162 b2、ChAdOx-nCov-2019和mRNA-1273）在不同肥胖类别（I、II、III和超级肥胖）个体中诱导抗SARS-CoV-2刺突（S）中和抗体的有效性。来自接种疫苗的肥胖个体（n = 73）和正常BMI对照（n = 46）的血清进行基于S的酶联免疫吸附测定（ELISA）和血清中和试验（SNT）以确定抗SARS-CoV-2中和抗体的流行率和滴度。还利用核衣壳蛋白-ELISA来区分仅通过接种获得的免疫与接种加从感染恢复获得的免疫。数据与参与者的人口统计数据相关联，包括年龄、性别、既往COVID-19诊断和COVID-19疫苗接种情况。基于S的ELISA显示研究组和对照组中的高血清阳性率（>97%），无论是否包括或排除具有既往感染证据的样本。然而，有趣的是，与对照组（45/46; 97.83%）相比，SNT在接种疫苗的肥胖个体（60/73; 82.19%）中证明了抗SARS-CoV-2中和抗体的比率和滴度的略微显著降低。在肥胖个体中观察到的COVID-19疫苗诱导的中和体液免疫力下降与性别、既往感染恢复情况和距离上次接种疫苗的时间无关。我们的数据表明，COVID-19疫苗在诱导保护性体液免疫方面非常有效。然而，这种有效性在肥胖个体中可能会降低，这突出了加强剂量对提高其中和免疫力的重要性。为了全面总结肥胖对COVID-19疫苗体液免疫诱导有效性的影响，仍有必要对更大样本量进行进一步研究。
Due to the adverse effects of obesity on host immunity, this study investigated the effectiveness of COVID-19 vaccines (BNT162b2, ChAdOx-nCov-2019, and mRNA-1273) in inducing anti-SARS-CoV-2 Spike (S) neutralizing antibodies among individuals with various obesity classes (class I, II, III, and super obesity). Sera from vaccinated obese individuals (n = 73) and normal BMI controls (n = 46) were subjected to S-based enzyme-linked immunosorbent assay (ELISA) and serum-neutralization test (SNT) to determine the prevalence and titer of anti-SARS-CoV-2 neutralizing antibodies. Nucleocapsid-ELISA was also utilized to distinguish between immunity acquired via vaccination only versus vaccination plus recovery from infection. Data were linked to participant demographics including age, gender, past COVID-19 diagnosis, and COVID-19 vaccination profile. S-based ELISA demonstrated high seroprevalence rates (>97%) in the study and control groups whether samples with evidence of past infection were included or excluded. Interestingly, however, SNT demonstrated a slightly significant reduction in both the rate and titer of anti-SARS-CoV-2 neutralizing antibodies among vaccinated obese individuals (60/73; 82.19%) compared to controls (45/46; 97.83%). The observed reduction in COVID-19 vaccine-induced neutralizing humoral immunity among obese individuals occurs independently of gender, recovery from past infection, and period from last vaccination. Our data suggest that COVID-19 vaccines are highly effective in inducing protective humoral immunity. This effectiveness, however, is potentially reduced among obese individuals which highlight the importance of booster doses to improve their neutralizing immunity. Further investigations on larger sample size remain necessary to comprehensively conclude about the effect of obesity on COVID-19 vaccine effectiveness on humoral immunity induction.
DOI：
10.3390/healthcare9121730
发表时间：
2021-12-14
期刊：
Healthcare (Basel, Switzerland)
影响因子：
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作者：
Alandijany TA;Faizo AA
通讯作者：
Faizo AA