THE WAVE LENGTH EFFECT UPON ERYTHEMAL AND CARCINOGENIC RESPONSE IN PSORALEN TREATED MICE
THE WAVE LENGTH EFFECT UPON ERYTHEMAL AND CARCINOGENIC RESPONSE IN PSORALEN TREATED MICE
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DOI：
10.1038/jid.1958.122
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发表时间：
1958-01-01
影响因子：
6.5
通讯作者：
KNOX, J
中科院分区：
文献类型：
--
作者：
GRIFFIN, AC;HAKIM, RE;KNOX, J
暴露于短波紫外线（2537AU）下的白化小鼠耳朵和眼睛出现红斑性损伤，其中约20%的小鼠在这些区域出现肿瘤。使用补骨脂素后，皮肤对这种短波长的反应没有变化。另一些白化小鼠暴露在长波紫外线（3200-4000 AU）下，眼睛和耳朵没有任何变化，也没有形成任何肿瘤。然而，给这些小鼠补骨脂素后，出现了迅速而严重的红斑反应，眼睛和耳朵的肿瘤发生率很高。
Albino mice exposed to short wave UV light (2537AU) evidenced erythemal damage in the ears and eyes, and approximately 20% of these animals developed tumors in these areas. With psoralen administration no alterations in the skin reactions to this short wave length were noted. Other albino mice were exposed to long wave length UV light (3200-4000 AU), and no changes were seen in their eyes or ears, nor were any tumors formed. However with administration of psoralen to these mice there resulted a rapid and severe erythemal reaction and a high tumor incidence in the eyes and ears.