Age-related loss of extrastriatal dopamine D2-like receptors in women
Age-related loss of extrastriatal dopamine D2-like receptors in women
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DOI：
10.1046/j.1471-4159.2002.00895.x
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发表时间：
2002-06-01
影响因子：
4.7
通讯作者：
Rinne, JO
中科院分区：
文献类型：
--
作者：
Kaasinen, V;Kemppainen, N;Rinne, JO
正电子发射断层扫描(PET)研究表明，在人脑中，多巴胺D-2样受体的体内利用率随着年龄的增长而下降。大多数研究都是在健康的男性受试者中进行的，或者是在包含两性的受试者组中进行的。作者最近证明，女性额叶皮质中D-2样受体的可获得性高于男性。本研究旨在进一步探讨这一现象。37名健康女性(年龄22-78岁)接受了PET和纹状体外D-2样受体的高亲和力示踪剂[C-11]FLB457的检查。在额叶皮质(每十年减少12%)、颞叶皮质(9%)和丘脑(6%)，年龄与多巴胺D-2样受体的可获得性呈负相关。S式的非线性关联仅在额叶皮质解释了这种关系，而在其他区域这种关联是线性的。在剔除年龄影响后，雌二醇和孕酮水平与大脑任何区域的[C-11]FLB457摄取都没有显著关系。结果表明：(I)健康女性纹状体外D-2样受体的可获得性随着年龄的增长而减少，其中额叶皮质的下降速度最快，总体比率接近健康男性的报道；(Ii)女性在中年(40-60岁)左右，额叶受体的可获得性下降平台期，而其他纹状体外脑区的降幅继续呈线性下降；(Iii)女性血清雌二醇或孕酮水平与皮质或丘脑D-2样受体可获得性无关。这一结果可能在研究多巴胺相关神经精神障碍患者临床性别差异的生化基础方面被证明是重要的。
Positron emission tomography (PET) studies have indicated that the in vivo availability of dopamine D-2 -like receptors declines with age in the human brain. Most of the studies have been carried out with healthy male subjects, or with subject groups containing both sexes. The authors have recently demonstrated that the availability of D-2 -like receptors in the frontal cortex is higher in women than in men. The present study was aimed to further examine this phenomenon. Thirty-seven healthy women (age range 22-78 years) were examined with PET and [C-11]FLB 457, a high-affinity tracer for the extrastriatal D-2-like receptors. A negative relationship between age and dopamine D-2-like receptor availability was seen in the frontal cortex (decrease of 12% per decade of life), the temporal cortex (9%) and the thalamus (6%). A non-linear s-shape association explained the relationship only in the frontal cortex, while in other regions the association was linear. Neither oestradiol nor progesterone levels had a significant relationship with the [C-11]FLB 457 uptake in any of the brain regions studied after the effect of age was partialled out. The results indicate that: (i) the extrastriatal D-2-like receptor availability decreases with age in healthy women with the fastest rate in the frontal cortex and with the overall rate close to the rate reported in healthy men; (ii) around midlife (age 40-60 years) in women, the frontal receptor decline plateaus while the decline continues to be linear in other extrastriatal brain regions; and (iii) serum oestradiol or progesterone levels are not associated with cortical or thalamic D-2 -like receptor availability in women. The results may prove to be important in studies where the biochemical basis of clinical sex differences is examined in patients with dopamine-related neuropsychiatric disorders.