Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer
Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer
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DOI：
10.1038/sj.onc.1200862
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发表时间：
1997-02-06
期刊：
影响因子：
8
通讯作者：
Strebhardt, K
中科院分区：
文献类型：
--
作者：
Wolf, G;Elez, R;Strebhardt, K
我们以前的数据表明，编码丝氨酸/苏氨酸激酶的PLK基因的表达仅限于增殖细胞。在北方印迹实验中，PLK mRNA表达在正常肺组织中处于检测极限，但在大多数非小细胞肺癌（NSCLC）样品中升高。一个非常低的频率PLK转录只发现在细支气管肺泡癌。PLK中度表达的NSCLC患者的5年生存率（51.8%）明显长于PLK高表达的NSCLC患者（24.2%，P=0.001）。PLK mRNA的表达与患者的年龄、性别、TNM分期、组织学类型及分化程度无明显相关性，但与术后I、II期患者的预后有关（I期5年生存率：69.1%（中度PLK）- 43.5%（高度PLK），P=0.03或II期：51.9%（中度PLK）- 9.9%（高度PLK），P=0.006）。这些结果表明，PLK mRNA的表达提供了一个新的独立的预后指标与NSCLC患者。
Our previous data indicate that the expression of the PLK gene which codes for a serine/threonine kinase is restricted to proliferating cells. In Northern blot experiments PLK mRNA expression was at the limit of detection in normal lung tissue but elevated in most samples of non-small cell lung cancer (NSCLC). A very low frequency of PLK transcripts was only found in bronchiolo-alveolar carcinomas. NSCLC patients whose tumors showed moderate PLK expression survived significantly longer (5 year survival rate=51.8%) than those with high levels of PLK transcripts (24.2%, P=0.001). No statistically significant correlation was found between PLK mRNA expression and age, sex, TNM status, histological type or degree of differentiation, Interestingly, the prognosis of patients in postsurgical stages I and II was correlated with PLK expression (5 year survival rates in stage I: 69.1% (moderate PLK) - 43.5% (high PLK), P=0.03 or in stage II: 51.9% (moderate PLK) - 9.9% (high PLK), P=0.006). These results suggest that PLK mRNA expression provides a new independent prognostic indicator for patients with NSCLC.