Induction of collateral circulation by hypoxia-inducible factor 1α decreased cerebral infarction in the rat
Induction of collateral circulation by hypoxia-inducible factor 1α decreased cerebral infarction in the rat
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DOI：
10.1179/174313209x383231
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发表时间：
2009-11-01
影响因子：
1.9
通讯作者：
Kobayashi, Hidenori
中科院分区：
文献类型：
--
作者：
Anan, Mitsuhiro;Abe, Tatsuya;Kobayashi, Hidenori
背景资料：我们最近报道了低氧诱导因子1 α（HIF-1 α），HIF-2 α和环氧合酶2裸DNA诱导大鼠间接旁路模型中的血管生成。在这项工作中，我们研究了是否HIF-1 α DNA诱导的侧支循环影响脑infarct.Methods：我们利用大鼠脑肌肉血管增生症（EMS）模型和HIF-1 α DNA接种到脑表面。这些治疗是在脑梗死发生之前进行的。随后，我们在EMS后第5天或第10天进行大脑中动脉闭塞。结果：用HIF-1 α DNA处理10天的组织切片显示侧支循环发育良好（p
Background: We recently reported that hypoxia-inducible factor 1 alpha (HIF-1 alpha), HIF-2 alpha and cyclooxygenase 2 naked DNA induced angiogenesis in a rat indirect bypass model. In this work, we investigated whether the collateral circulation induced by HIF-1 alpha DNA affected the cerebral infarction.Methods: We utilized a rat encephalomyosynangiosis (EMS) model and inoculated HIF-1 alpha DNA onto the brain surface. These treatments were performed before the cerebral infarction occurred. We thereafter performed middle cerebral artery occlusion on the fifth or tenth day after EMS.Results: A histological section treated with HIF-1 alpha DNA for 10 days showed a well-developed collateral circulation (p