Notch express-ion in developing olfactory neuroepithelium
Notch express-ion in developing olfactory neuroepithelium
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DOI：
10.1097/00001756-200404290-00003
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发表时间：
2004-04-29
期刊：
影响因子：
1.7
通讯作者：
Nibu, K
中科院分区：
文献类型：
--
作者：
Doi, K;Ishida, H;Nibu, K
Notch基因编码调节各种组织中神经发生的信号通路的受体。为了更好地了解Notch基因在嗅神经发生中的作用，我们研究了Notch家族在小鼠嗅上皮发育过程中的表达。在嗅觉发育的最早阶段，Notch1在嗅基板外侧的间充质中观察到。Notch1主要分布于嗅神经上皮基底膜周围，Notch3主要分布于嗅神经上皮下隔室。在整个观察期间未检测到Notch2。随着嗅神经上皮的成熟，Notch1和Notch3逐渐消失。这些结果表明Notch1和Notch3在外周嗅觉系统的神经发生中具有不同的作用。
Notch genes encode receptors for signaling pathways that regulate neurogenesis in various tissues. To better understand the roles of Notch genes in olfactory neurogenesis, we studied the expression of Notch family in developing mouse olfactory epithelium. In the earliest stage of olfactory development, Notch1 was observed in the mesenchyme lateral to the olfactory placode. During the developmental stage, Notch1 was mainly observed around the basal membrane, while Notch3 was observed in the lower compartment of the olfactory neuroepithelium. Notch2 was not detected during the entire observation period. As the olfactory neuroepithelium grew mature, both Notch1 and Notch3 gradually disappeared. These results suggest distinct roles of Notch1 and Notch3 in the neurogenesis of the peripheral olfactory system.