Performance of Amperometric Platinized-Nafion Based Gas Phase Sensor for Determining Nitric Oxide (NO) Levels in Exhaled Human Nasal Breath.
Performance of Amperometric Platinized-Nafion Based Gas Phase Sensor for Determining Nitric Oxide (NO) Levels in Exhaled Human Nasal Breath.
复制标题
基于安培铂化 Nafion 的气相传感器的性能，用于测定人鼻呼出气体中的一氧化氮 (NO) 水平。
DOI：
10.1002/elan.201800140
复制
发表时间：
2018
期刊：
影响因子：
3
通讯作者：
Meyerhoff,MarkE
中科院分区：
文献类型：
--
作者：
Zajda,Joanna;Schmidt,NicholasJ;Zheng,Zheng;Wang,Xuewei;Meyerhoff,MarkE
呼出气体中的一氧化氮（NO）水平是一种非侵入性标志物，可用于诊断各种呼吸系统疾病并监测患者对给定治疗的反应。需要一种便携式和廉价的装置，可以在呼出气体样本中进行选择性的NO浓度测量。本文研究了一种用于检测人类呼出的鼻气中NO的安培型Pt - Nafion气相传感器的性能。通过在线氧化锌基过滤器，提高了对一氧化碳和氨的选择性。使用该传感器测量的21个人体样本的呼出鼻腔NO水平与使用化学发光参考方法获得的水平具有良好的相关性（R2=0.9836）。
Nitric oxide (NO) levels in exhaled breath are a non‐invasive marker that can be used to diagnose various respiratory diseases and monitor a patient's response to given therapies. A portable and inexpensive device that can enable selective NO concentration measurements in exhaled breath samples is needed. Herein, the performance of an amperometric Pt‐Nafion‐based gas phase sensor for detection of NO in exhaled human nasal breath is examined. Enhanced selectivity over carbon monoxide and ammonia is achieved via an in‐line zinc oxide‐based filter. Exhaled nasal NO levels measured in 21 human samples with the sensor are shown to correlate well with those obtained using a chemiluminescence reference method (R2=0.9836).