A computational study on the influence of catheter-delivered intravascular probes on blood flow in a coronary artery model
A computational study on the influence of catheter-delivered intravascular probes on blood flow in a coronary artery model
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DOI：
10.1016/j.jbiomech.2006.11.004
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发表时间：
2007-01-01
影响因子：
2.4
通讯作者：
Xu, X. Yun.
中科院分区：
文献类型：
--
作者：
Torii, Ryo;Wood, Nigel B.;Xu, X. Yun.
导管输送血管内探头在临床上广泛用于测量冠状动脉血流速度和压力，但探头对被测变量的人为影响并不是很好的表征。用直径为3 mm的180度曲线管模拟冠状动脉，数值模拟脉动流动条件下不同直径导管的作用。导管的存在使压力增加1.3-4.3毫米汞柱，这取决于导管的直径，并减少了速度-压力相位滞后。对于探头末端下游5 mm的超声样本体积，当平均入口速度为0时，由于导管堵塞而导致的速度测量中的低估约为15-21%。1m/S，平均流速越大，测速误差越小。通过将样本体积从探头尖端向下游移动更远，可以提高临床速度测量的准确性，因为曲率固有的离心力梯度促进了流动的再发展。(C)2006年，爱思唯尔有限公司出版。
Catheter-delivered intravascular probes are widely used in clinical practice to measure coronary arterial velocity and pressure, but the artefactual effect of the probe on the variables being measured is not well characterised. A coronary artery was Simulated with a 180 degrees Curved tube 3 mm in diameter and the effect of catheters of different diameters was modelled numerically under pulsatile flow conditions. The presence of a catheter increased pressure by 1.3-4.3 mmHg depending on its diameter, and reduced velocity-pressure phase-lag. For an ultrasound sample Volume 5 mm downstream from the probe tip, the underestimation in velocity measurement attributed to catheter blockage is approximately 15-21 % for an average inlet velocity of 0. 1 m/s. The velocity measurement error is lower at higher mean flow velocity. Accuracy of clinical velocity measurements could be improved by moving the sample volume farther downstream from the probe tip, because the centrifugal pressure gradient intrinsic to the curvature promotes re-development of flow. (c) 2006 Published by Elsevier Ltd.