INFLUENCE OF APNEA TYPE AND SLEEP STAGE ON NOCTURNAL POSTAPNEIC DESATURATION
INFLUENCE OF APNEA TYPE AND SLEEP STAGE ON NOCTURNAL POSTAPNEIC DESATURATION
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DOI：
10.1164/ajrccm/141.6.1522
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发表时间：
1990-06-01
期刊：
影响因子：
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通讯作者：
LAFORGE, J
中科院分区：
文献类型：
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作者：
SERIES, F;CORMIER, Y;LAFORGE, J
我们研究了32例睡眠呼吸暂停综合征患者的呼吸暂停类型和睡眠阶段对呼吸暂停引起的去饱和度严重程度的影响。通过去饱和曲线评价个体呼吸后去饱和;该曲线通过绘制呼吸暂停后SaO 2下降与整个夜间记录期间每个呼吸暂停事件的呼吸暂停长度来构建。我们仅考虑呼吸暂停前SaO 2大于90%，呼吸暂停后最低SaO 2值等于或大于60%（血氧计的线性限度）的呼吸暂停。根据去饱和曲线，我们确定了去饱和表面，该去饱和表面定义为10 s和可变呼吸暂停持续时间之间的曲线下面积。用于确定去饱和曲线和去饱和表面的上限是在非REM阻塞性呼吸暂停和其他呼吸暂停类型之间具有最短呼吸暂停持续时间的呼吸暂停类型的最大长度（即，阻塞性和中枢性呼吸暂停、阻塞性和混合性呼吸暂停等）。分别测定非REM睡眠呼吸暂停（阻塞性呼吸暂停、混合性呼吸暂停、中枢性呼吸暂停和阻塞性呼吸暂停伴持续呼气流量）和REM睡眠呼吸暂停（均为阻塞性）的去饱和表面。非REM阻塞性呼吸暂停作为参考，以评估其他呼吸暂停引起的去饱和度的严重程度。我们发现阻塞性呼吸暂停（OA）的呼气流量和REM睡眠OA的去饱和表面显著大于非REM睡眠OA（p <0.05）。0.005）。OA相关的去饱和度显著大于中枢性呼吸暂停（p = 0.005）。我们的研究结果表明，呼吸暂停类型和睡眠阶段的影响夜间呼吸暂停后福尔斯下降SaO 2独立的呼吸暂停长度。
We examined the influence of apnea type and sleep stage on the severity of apnea-induced desaturations in 32 patients with a sleep apnea syndrome. The individual postapneic desaturations were evaluated by a desaturation curve; this curve was built by plotting the fall in SaO2 after an apnea against this apnea''s length for each apneic event during the whole night recording. We considered only apneas where the preapneic SaO2 was greater than 90% and the lowest SaO2 value after the apnea was equal to or greater than 60% (limit of linearity of our oximeter). From the desaturation curve, we determined a desaturation surface defined as the area under the curve between 10 s and a variable apnea duration. The upper bound used for the determination of the desaturation curve and the desaturation surface was the maximal length of apnea type with the shortest apnea duration between non-REM obstructive apnea and the other apnea types (i.e., obstructive and central apnea, obstructive and mixed apnea, etc.). The desaturation surface was determined separately for non-REM sleep apneas (obstructive apneas, mixed apneas, central apneas, and obstructive apneas with persistent expiratory flow) and REM sleep apnea (all obstructive in type). None-REM obstructive apneas served as reference to evaluate the severity of apnea-induced desaturations of the other apneas. We found that the desaturation surface of obstructive apnea (OA) with expiratory flow and of REM sleep OA were significantly greater than for OA in non-REM sleep (p .ltoreq. 0.005). The OA-related desaturation was significantly greater than those of central apneas (p = 0.005). Our results demonstrate that apnea type and sleep stage influence nocturnal postapneic falls in SaO2 independently of the apnea length.