Mechanisms of deep brain stimulation in movement disorders as revealed by changes in stimulus frequency
Mechanisms of deep brain stimulation in movement disorders as revealed by changes in stimulus frequency
复制标题
DOI：
10.1016/j.nurt.2007.10.067
复制
发表时间：
2008-01-01
影响因子：
5.7
通讯作者：
Grill, Warren M.
中科院分区：
文献类型：
--
作者：
Birdno, Merrill J.;Grill, Warren M.
脑深部电刺激（DBS）是一种治疗运动障碍症状的既定疗法，目前正在研究用于精神疾病和癫痫患者的症状管理。然而，仍然存在分歧的生理机制负责DBS的行动，这种缺乏了解阻碍了DBS系统的设计，用于治疗新的疾病和有效调整目前的DBS系统。目前可用的数据表明，有效的DBS覆盖病理性爆发，低频振荡，同步，和中断的发射模式中存在的运动障碍，并取代它们与更有规律的发射。虽然DBS发挥其作用的具体机制可能因疾病和靶核而异，但病理活动的覆盖似乎是普遍存在的。本综述概述了DBS频率变化引起的运动症状变化，并强调了运动症状变化与运动症状基础细胞活动变化之间的相似之处。
Deep brain stimulation (DBS) is an established treatment for symptoms in movement disorders and is under investigation for symptom management in persons with psychiatric disorders and epilepsy. Nevertheless, there remains disagreement regarding the physiological mechanisms responsible for the actions of DBS, and this lack of understanding impedes both the design of DBS systems for treating novel diseases and the effective tuning of current DBS systems. Currently available data indicate that effective DBS overrides pathological bursts, low frequency oscillations, synchronization, and disrupted firing patterns present in movement disorders, and replaces them with more regularized firing. Although it is likely that the specific mechanism(s) by which DBS exerts its effects varies between diseases and target nuclei, the overriding of pathological activity appears to be ubiquitous. This review provides an overview of changes in motor symptoms with changes in DBS frequency and highlights parallels between the changes in motor symptoms and the changes in cellular activity that appear to underlie the motor symptoms.