Nuclear Methods for Immune Cell Imaging: Bridging Molecular Imaging and Individualized Medicine.
Nuclear Methods for Immune Cell Imaging: Bridging Molecular Imaging and Individualized Medicine.
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DOI：
10.1161/circimaging.122.014067
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发表时间：
2023-01
期刊：
影响因子：
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通讯作者：
G. Heo;J. Diekmann;J. Thackeray;Yongjian Liu
中科院分区：
文献类型：
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作者：
G. Heo;J. Diekmann;J. Thackeray;Yongjian Liu
炎症是心血管疾病进展的关键机制，从动脉粥样硬化到缺血性损伤和明显的心力衰竭。最近的证据已经确定了免疫细胞亚群在心脏发病机制中的特定作用，该作用在个体患者之间存在差异。核成像方法有助于对炎症严重程度进行无创和连续量化，提供预测最终结果、分层患者风险并指导针对特定白细胞亚群的新型靶向分子治疗的机会。在这里，我们将讨论用于标记和跟踪外源性和内源性免疫细胞的已建立和新兴的核成像方法，特别关注靶向分子炎症成像具有优势的临床情况。炎症成像的不断扩展的选择为分子成像和个体治疗之间的桥梁奠定了基础。
Inflammation is a key mechanistic contributor to the progression of cardiovascular disease, from atherosclerosis through ischemic injury and overt heart failure. Recent evidence has identified specific roles of immune cell subpopulations in cardiac pathogenesis that diverges between individual patients. Nuclear imaging approaches facilitate noninvasive and serial quantification of inflammation severity, offering the opportunity to predict eventual outcome, stratify patient risk, and guide novel targeted molecular therapies against specific leukocyte subpopulations. Here, we will discuss the established and emerging nuclear imaging methods to label and track exogenous and endogenous immune cells, with a particular focus on clinical situations in which targeted molecular inflammation imaging would be advantageous. The expanding options for imaging inflammation provide the foundation to bridge between molecular imaging and individual therapy.