Molecular and cellular mechanisms in spermatogenesis
Molecular and cellular mechanisms in spermatogenesis
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DOI：
10.1053/beem.2000.0083
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发表时间：
2000-09-01
影响因子：
7.4
通讯作者：
Baarends, WM
中科院分区：
文献类型：
--
作者：
Grootegoed, JA;Siep, M;Baarends, WM
哺乳动物精子发生是一个严格控制的许多特定的分子和细胞事件。这种控制涉及支持细胞-生殖细胞的相互作用，以及在发育中的生殖细胞中染色质结构和基因表达变化的程序化表现。近年来，通过利用小鼠转基因和基因敲除模型，人们对精子发生中特定基因的功能有了更多的了解。在这个简要的概述中讨论了这些模型中的几个，重点是编码参与基因转录，mRNA翻译，DNA修复和蛋白质泛素化控制的蛋白质的基因。更好地了解小鼠精子发生的分子和细胞生物学可能提供的概念，可以提高我们对人类男性不育症的理解，也可能导致避孕干预的新目标的确定。
Mammalian spermatogenesis shows a strict control of many specific molecular and cellular events. This control involves Sertoli cell-germ cell interaction, as well as a programmed performance of changes in chromatin structure and gene expression in the developing germ cells. In recent years, much knowledge about the functions of defined genes in spermatogenesis has been gained by making use of mouse transgenic and gene knockout models. Several of these models are discussed in this brief overview, with an emphasis on genes encoding proteins involved in the control of gene transcription, mRNA translation, DNA repair and protein ubiquitination. A better understanding of the molecular and cellular biology of spermatogenesis in the mouse may provide concepts that can improve our understanding of human male infertility and may also lead to the identification of novel targets for contraceptive intervention.