Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction
Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction
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DOI：
10.1097/mca.0b013e328342c77b
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发表时间：
2011-05-01
影响因子：
1.8
通讯作者：
Gibson, C. Michael
中科院分区：
文献类型：
--
作者：
Uyarel, Huseyin;Ergelen, Mehmet;Gibson, C. Michael
Objectives Red cell distribution width (RDW), a measure of red blood cell size heterogeneity, was evaluated in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI).Background Higher RDW is associated with mortality in patients with symptomatic cardiovascular disease, heart failure, and also in the general population. We hypothesized that admission RDW would be predictive of adverse outcomes in patients after primary PCI.Methods Two thousand five hundred and six consecutive STEMI patients (mean age 56.6 +/- 11.8 years; 2075 males, 431 females) undergoing primary PCI were retrospectively enrolled into this study. Admission RDW was measured as part of the automated complete blood count. Patients were grouped as elevated or nonelevated RDW using the upper limit of normal value of 14.8% and were followed for in-hospital and long-term outcomes for a mean period of 1.8 +/- 1.3 years (median 21 months).Results A higher in-hospital mortality rate was observed among patients with elevated admission RDW (mean 16.1 +/- 1.6%) compared with those with nonelevated RDW (mean 13.4 +/- 0.8%) (7.6 vs. 3.6%, P < 0.001). The long-term cardiovascular prognosis was worse for patients with elevated admission RDW (Kaplan-Meier, log-rank P
