The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration
The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration
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DOI：
10.1038/nbt1346
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发表时间：
2007-11-01
影响因子：
46.9
通讯作者：
Lewis, Suzanna
中科院分区：
文献类型：
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作者：
Smith, Barry;Ashburner, Michael;Lewis, Suzanna
当任何类型的数据以允许其与其他数据集成的形式存在时，任何类型的数据的价值都会大大增强。一种集成的方法是使用常见的受控词汇或“本体”对多个数据体的注释。不幸的是，这种方法的成功导致了本体论的扩散，这本身就造成了整合的障碍。开放的生物医学本体（OBO）财团正在采取一种克服这一问题的策略。现有的OBO本体论，包括基因本体论，正在进行协调的改革，并基于一套不断发展的共同原则来建立新的本体论。结果是一个不断扩展的本体家族，旨在可互操作且逻辑上形成良好，并结合了生物现实的准确表示。我们描述了这项OBO铸造计划，并为希望参与其中的人提供指南。
The value of any kind of data is greatly enhanced when it exists in a form that allows it to be integrated with other data. One approach to integration is through the annotation of multiple bodies of data using common controlled vocabularies or 'ontologies'. Unfortunately, the very success of this approach has led to a proliferation of ontologies, which itself creates obstacles to integration. The Open Biomedical Ontologies (OBO) consortium is pursuing a strategy to overcome this problem. Existing OBO ontologies, including the Gene Ontology, are undergoing coordinated reform, and new ontologies are being created on the basis of an evolving set of shared principles governing ontology development. The result is an expanding family of ontologies designed to be interoperable and logically well formed and to incorporate accurate representations of biological reality. We describe this OBO Foundry initiative and provide guidelines for those who might wish to become involved.