Polypoidal choroidal vasculopathy and exudative age-related macular degeneration in Greek population
Polypoidal choroidal vasculopathy and exudative age-related macular degeneration in Greek population
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DOI：
10.1038/sj.eye.6700706
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发表时间：
2004-05-01
期刊：
影响因子：
3.9
通讯作者：
Koutsandrea, CN
中科院分区：
文献类型：
--
作者：
Ladas, ID;Rouvas, AA;Koutsandrea, CN
目的研究大量希腊渗出性黄斑病变患者中息肉状脉络膜血管病变（PCV）的患病率、临床特征和未经治疗的视力预后。方法收集268例连续的老年白色希腊患者的病历、照片以及荧光素和吲哚菁绿色（ICG）血管造影片，结果在268例最初怀疑为AMD的患者中，22例（8.2%）最终诊断为PCV。PCV患者中15例（68.2%）息肉样病变位于乳头周围区。10例（20%）单侧PCV患者中只有2只对侧眼出现大的软性玻璃疣，而148例（81.1%）单侧AMD患者中有120只对侧眼出现大的软性玻璃疣。在最后一次检查中，11的22例（50%）PCV和120的246例（48.8%）AMD患者的视力低于6/60，至少有一只眼睛由于瘢痕形成macula.Conclusions PCV是不是一个罕见的疾病在希腊。可测量数量的发现提示渗出性AMD的希腊患者将改为PCV。ICG血管造影在区分这两种临床实体方面很重要。在希腊人中，息肉样病变主要发生在视乳头周围，通常与对侧眼的黄斑玻璃疣无关。PCV和渗出性AMD在希腊患者的自然病程和视力预后方面没有显著差异。
Purpose To study the prevalence, the clinical features, and the visual prognosis without treatment of polypoidal choroidal vasculopathy (PCV) in a large series of Greek patients presenting with exudative maculopathy.Methods The medical records, photographs, as well as fluorescein and indocyanine green (ICG) angiograms of a series of 268 consecutive elderly white Greek patients, who were originally diagnosed as having exudative age - related macular degeneration (AMD) were reviewed retrospectively.Results In all, 22 of the 268 (8.2%) patients initially suspected of having AMD were ultimately diagnosed with PCV. In 15 of the 22 (68.2%) patients with PCV, the polypoidal lesions were located in the peripapillary area. Large soft drusen were present in only two fellow eyes of the 10 (20%) patients with unilateral PCV compared with 120 fellow eyes of the 148 (81.1%) patients with unilateral AMD. At the last examination, 11 of the 22 (50%) patients with PCV and 120 of the 246 (48.8%) patients with AMD presented a visual acuity of less than 6/60 in at least one eye due to scar formation in the macula.Conclusions PCV is not an infrequent disease in Greece. A measurable number of Greek patients with findings suggestive of exudative AMD will instead have PCV. ICG angiography is important in differentiating between these two clinical entities. In Greeks, polypoidal lesions are predominately peripapillary and are not usually associated with macular drusen in the fellow eye. PCV and exudative AMD do not differ significantly in terms of their natural course and visual prognosis in Greek patients.