Animal models of gastrointestinal and liver diseases. New mouse models for studying dietary prevention of colorectal cancer.
Animal models of gastrointestinal and liver diseases. New mouse models for studying dietary prevention of colorectal cancer.
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DOI：
10.1152/ajpgi.00019.2014
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发表时间：
2014-08
期刊：
影响因子：
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通讯作者：
J. Fleet
中科院分区：
文献类型：
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作者：
J. Fleet
结直肠癌是一种异质性疾病，是美国癌症死亡的主要原因之一。有证据表明，饮食等生活方式因素可以调节这种疾病的进程。要证明饮食干预对结肠癌的益处和作用机制，需要在临床前模型中进行研究。已经开发了许多小鼠模型来研究结肠癌，但没有一个单一的模型可以在分子病因学方面反映所有类型的结肠癌。此外，许多模型仅发展低度癌症，并且被结肠外疾病的发展所混淆。这篇综述将讨论小鼠如何被用来模拟人类结肠癌，并将描述各种新的小鼠模型，发展结肠限制性癌症以及更先进的表型的晚期疾病的研究。
Colorectal cancer is a heterogeneous disease that is one of the major causes of cancer death in the U.S. There is evidence that lifestyle factors like diet can modulate the course of this disease. Demonstrating the benefit and mechanism of action of dietary interventions against colon cancer will require studies in preclinical models. Many mouse models have been developed to study colon cancer but no single model can reflect all types of colon cancer in terms of molecular etiology. In addition, many models develop only low-grade cancers and are confounded by development of the disease outside of the colon. This review will discuss how mice can be used to model human colon cancer and it will describe a variety of new mouse models that develop colon-restricted cancer as well as more advanced phenotypes for studies of late-state disease.