Shape-morphing living composites
Shape-morphing living composites
复制标题
DOI：
10.1126/sciadv.aax8582
复制
发表时间：
2020-01
期刊：
影响因子：
13.6
通讯作者：
Laura K. Rivera‐Tarazona;Vandita D Bhat;Hyun Kim;Z. Campbell;T. Ware
中科院分区：
文献类型：
--
作者：
Laura K. Rivera‐Tarazona;Vandita D Bhat;Hyun Kim;Z. Campbell;T. Ware
嵌入水凝胶中的面包酵母使智能材料的工程能够根据特定的线索改变形状。这项工作建立了一种利用遗传网络来创造活的合成复合材料的方法，这些复合材料可以响应特定的生化或物理刺激而改变形状。包埋在水凝胶中的面包酵母形成了一种响应性材料，其中细胞增殖导致复合材料体积可控增加高达400%。酵母的遗传操作使复合材料暴露于l-组氨酸时的体积变化比暴露于d-组氨酸或其他氨基酸时的体积变化高14倍。通过将光遗传学开关编码到酵母中，时空控制的形状变化用暗淡的蓝光脉冲（2.7mW/cm 2）诱导。这些有生命的、形状变化的材料可以使传感器或医疗设备对生物环境中发现的高度特异性的线索做出反应。
Baker’s yeast embedded in a hydrogel enables the engineering of smart materials that change shape in response to specific cues. This work establishes a means to exploit genetic networks to create living synthetic composites that change shape in response to specific biochemical or physical stimuli. Baker’s yeast embedded in a hydrogel forms a responsive material where cellular proliferation leads to a controllable increase in the composite volume of up to 400%. Genetic manipulation of the yeast enables composites where volume change on exposure to l-histidine is 14× higher than volume change when exposed to d-histidine or other amino acids. By encoding an optogenetic switch into the yeast, spatiotemporally controlled shape change is induced with pulses of dim blue light (2.7 mW/cm2). These living, shape-changing materials may enable sensors or medical devices that respond to highly specific cues found within a biological milieu.