SBR-Blood: systems biology repository for hematopoietic cells.
SBR-Blood: systems biology repository for hematopoietic cells.
复制标题
DOI：
10.1093/nar/gkv1263
复制
发表时间：
2016-01-04
影响因子：
14.9
通讯作者：
Bodine DM
中科院分区：
文献类型：
--
作者：
Lichtenberg J;Heuston EF;Mishra T;Keller CA;Hardison RC;Bodine DM
几十年来对造血（血细胞的发育）的广泛研究已经在多种人类和小鼠血细胞类型中产生了大量的表达和表观遗传谱。然而，没有单一的位置来分析基因调节过程如何导致不同的成熟血细胞。我们已经开发了一种新的数据库框架，称为造血系统生物学知识库（SBR-Blood），可在http://sbrblood.nhgri.nih.gov上在线获得，该框架允许用户启动细胞类型相关性或分化期间的基因特异性行为的分析，使用公开可用的数据集，用于小鼠造血细胞的基于阵列和测序的平台。SBR-Blood通过细胞身份和造血谱系组织信息。通过复制与表达数据、DNA甲基化、组蛋白修饰和转录因子占用谱相关的工作流程，确定了SBR-血液的有效性和可用性。
Extensive research into hematopoiesis (the development of blood cells) over several decades has generated large sets of expression and epigenetic profiles in multiple human and mouse blood cell types. However, there is no single location to analyze how gene regulatory processes lead to different mature blood cells. We have developed a new database framework called hematopoietic Systems Biology Repository (SBR-Blood), available online at http://sbrblood.nhgri.nih.gov, which allows user-initiated analyses for cell type correlations or gene-specific behavior during differentiation using publicly available datasets for array- and sequencing-based platforms from mouse hematopoietic cells. SBR-Blood organizes information by both cell identity and by hematopoietic lineage. The validity and usability of SBR-Blood has been established through the reproduction of workflows relevant to expression data, DNA methylation, histone modifications and transcription factor occupancy profiles.