Mesenchymal stem cells as trophic mediators
Mesenchymal stem cells as trophic mediators
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DOI：
10.1002/jcb.20886
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发表时间：
2006-08-01
影响因子：
4
通讯作者：
Dennis, James E.
中科院分区：
文献类型：
--
作者：
Caplan, Arnold I.;Dennis, James E.
成人骨髓来源的间充质干细胞（MSC）能够分裂，并且它们的后代能够进一步分化成几种间充质表型之一，例如成骨细胞、软骨细胞、肌细胞、骨髓基质细胞、腱韧带成纤维细胞和脂肪细胞。此外，这些MSC分泌多种细胞因子和生长因子，具有旁分泌和自分泌活性。这些分泌的生物活性因子抑制局部免疫系统，抑制纤维化（瘢痕形成）和细胞凋亡，增强血管生成，并刺激组织内在修复细胞或干细胞的有丝分裂和分化。这些效应被称为营养效应，与MSC直接分化为修复组织不同。在MSC介导的组织修复营养效应的背景下，对几项研究进行了综述，这些研究测试了MSC在梗死（心脏损伤）、中风（脑）或半月板再生模型中的应用。
Adult marrow-derived Mesenchymal Stem Cells (MSCs) are capable of dividing and their progeny are further capable of differentiating into one of several mesenchymal phenotypes such as osteoblasts, chondrocytes, myocytes, marrow stromal cells, tendon-ligament fibroblasts, and adipocytes. In addition, these MSCs secrete a variety of cytokines and growth factors that have both paracrine and autocrine activities. These secreted bioactive factors suppress the local immune system, inhibit fibrosis (scar formation) and apoptosis, enhance angiogenesis, and stimulate mitosis and differentiation of tissue-intrinsic reparative or stem cells. These effects, which are referred to as trophic effects, are distinct from the direct differentiation of MSCs into repair tissue. Several studies which tested the use of MSCs in models of infarct (injured heart), stroke (brain), or meniscus regeneration models are reviewed within the context of MSC-mediated trophic effects in tissue repair.