Body Mass Index Has a Linear Relationship with Cerebrospinal Fluid Pressure
Body Mass Index Has a Linear Relationship with Cerebrospinal Fluid Pressure
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DOI：
10.1167/iovs.11-8220
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发表时间：
2012-03-01
影响因子：
4.4
通讯作者：
Fautsch, Michael P.
中科院分区：
文献类型：
--
作者：
Berdahl, John P.;Fleischman, David;Fautsch, Michael P.
目的.研究低体重指数（BMI）和低脑脊液压（CSFP）与原发性开角型青光眼（POAG）的关系。这是对马约诊所（罗切斯特，MN）通过腰椎穿刺测量CSFP的患者电子病历和计算BMI的数据进行的回顾性审查。排除标准包括诊断、外科手术和已知影响CSFP的药物。计算每个单位BMI的平均CSFP。概率为双尾，α水平设定为P < 0.05。对记录有BMI、CSFP和眼内压（IOP）的患者分析IOP与BMI之间的关系。共有4235例患者符合入选标准，主要为白人后裔。中位BMI为26，平均CSFP为10.9 ± 2.6 mm Hg。CSFP随BMI增加呈线性增加，r（2）= 0.20（P < 0.001）。从BMI 18（8.6 +/- 2.1 mm Hg）到BMI 39（14.1 +/-2.5 mm Hg），CSFP增加了37.7%。BMI和性别模型的r（2）（0.21）与仅BMI模型的r（2）（0.20）相似。在研究人群的一个亚组中，IOP与BMI之间无相关性（r（2）= 0.005; P = 0.14）。CSFP与BMI呈线性正相关。IOP不受BMI的影响。如果CSFP影响POAG的风险，那么BMI较低的个体可能会增加患POAG的风险。同样，较高的BMI可能具有保护作用。（Invest Ophthalmol维斯科学。2012;53：1422-1427）DOI：10.1167/iovs.11-8220
PURPOSE. To examine the relationship between body mass index (BMI) and cerebrospinal fluid pressure (CSFP), as low BMI and low CSFP have recently been described as risk factors for primary open-angle glaucoma (POAG).METHODS. This was a retrospective review of the electronic medical records of patients who had CSFP measured by lumbar puncture and data to calculate BMI at the Mayo Clinic (Rochester, MN). Exclusion criteria included diagnoses, surgical procedures and medications known to affect CSFP. Mean CSFP for each unit BMI was calculated. The probabilities were two-tailed, and the alpha level was set at P < 0.05. Patients with documented BMI, CSFP, and intraocular pressure (IOP) were analyzed for the relationship between IOP and BMI.RESULTS. A total of 4235 patients, primarily of Caucasian descent, met the entry criteria. Median BMI was 26 and the mean CSFP was 10.9 +/- 2.6 mm Hg. The increase in CSFP with increasing BMI was linear with an r(2) = 0.20 (P < 0.001). CSFP increased by 37.7% from BMI 18 (8.6 +/- 2.1 mm Hg) to BMI 39 (14.1 +/- 2.5 mm Hg). The r(2) (0.21) of the model of BMI and sex was similar to the r(2) of a BMI-only model (0.20). There was no relation between IOP and BMI within a subgroup of the study population (r(2) = 0.005; P = 0.14).CONCLUSIONS. CSFP has a positive, linear relationship with BMI. IOP is not influenced by BMI. If CSFP influences the risk for POAG, then individuals with a lower BMI may have an increased risk for developing POAG. Similarly, a higher BMI may be protective. (Invest Ophthalmol Vis Sci. 2012;53:1422-1427) DOI:10.1167/iovs.11-8220