Treatment of Iron Deficiency Anemia in CKD and End-Stage Kidney Disease.
Treatment of Iron Deficiency Anemia in CKD and End-Stage Kidney Disease.
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DOI：
10.1016/j.ekir.2021.05.020
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发表时间：
2021-09
影响因子：
6
通讯作者：
Gutiérrez OM
中科院分区：
文献类型：
--
作者：
Gutiérrez OM
缺铁在慢性肾脏疾病患者中很常见，在贫血的发展中起着主要作用。对于被诊断为缺铁的慢性肾脏疾病患者，口服铁剂和静脉铁剂都可用于补充铁。选择使用哪种药物通常取决于治疗目标、耐受性、便利性和对先前治疗的反应。胃肠道对铁的吸收减少和胃肠道不良反应的发生率高会降低口服铁剂的疗效，因此需要静脉注射。治疗缺铁性贫血的铁制剂，特别是需要肾脏替代疗法的患者。较新的口服药物可能有助于克服这些限制，并有助于治疗那些不需要肾脏替代疗法的人的铁缺乏。最近的研究提供了新的证据，表明在需要肾脏替代治疗的慢性肾脏疾病患者中，更积极的铁补充可能会在贫血治疗和心血管疾病和生存等硬性临床结果方面提供好处。
Iron deficiency is common in individuals with chronic kidney disease and plays a major role in the development of anemia. Oral and intravenous iron agents are both available to replete iron in patients with chronic kidney disease diagnosed with iron deficiency. The choice of which agent to use is most often dictated by goals of therapy, tolerability, convenience, and response to prior therapy. Diminished absorption of iron in the gastrointestinal tract and a high incidence of gastrointestinal adverse effects can reduce the efficacy of oral iron agents, necessitating the use of i.v. iron formulations to treat iron deficiency anemia, particularly in patients requiring kidney replacement therapy. Newer oral agents may help to overcome these limitations and help treat iron deficiency in those not requiring kidney replacement therapy. Recent studies have provided new evidence that more aggressive repletion of iron in patients with chronic kidney disease requiring kidney replacement therapy may provide benefits with respect to anemia management and hard clinical outcomes such as cardiovascular disease and survival.
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DOI：
10.1093/ndt/gfv277
发表时间：
2015-12
期刊：
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
影响因子：
--
作者：
Fishbane SN;Singh AK;Cournoyer SH;Jindal KK;Fanti P;Guss CD;Lin VH;Pratt RD;Gupta A
通讯作者：
Gupta A
影响因子：
19.6
作者：
Agarwal R;Kusek JW;Pappas MK
通讯作者：
Pappas MK
影响因子：
29
作者：
Donovan, A;Lima, CA;Andrews, NC
通讯作者：
Andrews, NC
影响因子：
13.6
作者：
Besarab, Anatole;Chernyayskaya, Elena;Neff, Thomas B.
通讯作者：
Neff, Thomas B.
影响因子：
4.8
作者：
Abboud, S;Haile, DJ
通讯作者：
Haile, DJ