Properties of synaptic transmission and the global stability of delayed activity states
Properties of synaptic transmission and the global stability of delayed activity states
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DOI：
10.1088/0954-898x/12/1/304
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发表时间：
2001-02-01
影响因子：
7.8
通讯作者：
Koulakov, AA
中科院分区：
文献类型：
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作者：
Koulakov, AA
研究了突触通道特性对递归神经网络延迟活动稳定性的影响。兴奋性突触后电流（EPSC）的持续时间被证明是必不可少的延迟反应的全局稳定性。由于较长的EPSC，NMDA受体通道是比AMPA受体更可靠的混响活性的介体。这使得人们能够解释在NMDA通道阻断实验中观察到的工作记忆的恶化。导致延迟活动衰减的关键机制源于突触传递的不可靠性。确定了导致衰减的突触电流的最佳波动。用解析法计算了衰减时间，并通过计算证实了结果。
The influence of synaptic channel properties on the stability of delayed activity maintained by recurrent neural networks is studied. The duration of excitatory post-synaptic current (EPSC) is shown to be essential for the global stability of the delayed response. The NMDA receptor channel is a much more reliable mediator of the reverberating activity than the AMPA receptor, due to a longer EPSC. This allows one to interpret the deterioration of the working memory observed in NMDA channel blockade experiments. The key mechanism leading to the decay of the delayed activity originates in the unreliability of synaptic transmission. The optimum fluctuation of the synaptic currents leading to the decay is identified. The decay time is calculated analytically and the result is confirmed computationally.