Application of Biofilm Bioreactors in White Biotechnology
Application of Biofilm Bioreactors in White Biotechnology
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DOI：
10.1007/10_2013_267
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发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Ulber, R.
中科院分区：
文献类型：
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作者：
Muffler, K.;Lakatos, M.;Ulber, R.
在工业生物技术中，有价值化合物的生产通常通过培养悬浮细胞或使用（固定化）酶而不是使用固定化状态的微生物来进行。在废水和气味处理领域中，固定化细胞的应用是一种成熟的技术。细胞被捕获在由它们自身产生的细胞外聚合化合物的基质中。被包裹的细胞的表面相关聚集体被称为生物膜。与普通固定化技术相比，用于细胞包埋的化合物的毒性作用可以忽略不计。虽然用于生产有价值的化合物的生物膜过程的经济影响是可以忽略不计的，许多前瞻性的方法进行了检查，在实验室和中试规模。本文综述了生物膜反应器在有价值化合物生产中的应用。此外，所利用的材料的特性进行了讨论相对于支持表面附着的微生物生长。
The production of valuable compounds in industrial biotechnology is commonly done by cultivation of suspended cells or use of (immobilized) enzymes rather than using microorganisms in an immobilized state. Within the field of wastewater as well as odor treatment the application of immobilized cells is a proven technique. The cells are entrapped in a matrix of extracellular polymeric compounds produced by themselves. The surface-associated agglomerate of encapsulated cells is termed biofilm. In comparison to common immobilization techniques, toxic effects of compounds used for cell entrapment may be neglected. Although the economic impact of biofilm processes used for the production of valuable compounds is negligible, many prospective approaches were examined in the laboratory and on a pilot scale. This review gives an overview of biofilm reactors applied to the production of valuable compounds. Moreover, the characteristics of the utilized materials are discussed with respect to support of surface-attached microbial growth.