Preparation of porous hydroxyapatite scaffolds
Preparation of porous hydroxyapatite scaffolds
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DOI：
10.1016/j.msec.2006.05.038
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发表时间：
2007-04
期刊：
影响因子：
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通讯作者：
E. Saiz;L. Grémillard;G. Menéndez;P. Miranda;K. Gryń;A. Tomsia
中科院分区：
文献类型：
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作者：
E. Saiz;L. Grémillard;G. Menéndez;P. Miranda;K. Gryń;A. Tomsia
在这项工作中，分析了羟基磷灰石生坯的烧结和晶粒生长，以确定制备多孔羟基磷灰石支架的最佳热处理。在 1100 至 1200 °C 的温度下在空气中烧结可产生具有窄晶粒尺寸分布的致密材料。该支架是通过羟基磷灰石浆料渗透聚合物泡沫或通过机器人铸造（一种新型快速原型技术）形成的。给出了用每种方法实现的微观结构的示例。据观察，这两种技术都可以用来制造具有足够孔径的支架，以促进骨向内生长。
In this work, the sintering and grain growth of hydroxyapatite green bodies are analyzed in order to identify the optimum heat treatments for the preparation of porous hydroxyapatite scaffolds. Sintering in air at temperatures ranging between 1100 and 1200 °C yields dense materials with narrow grain-size distributions. The scaffolds are formed by the infiltration of polymer foams with hydroxyapatite slurries or by robocasting, a novel rapid-prototyping technique. Examples of the microstructures achieved with each approach are presented. It is observed that both techniques can be used to fabricate scaffolds with adequate pore size to promote bone ingrowth.