Estimating changes in free-living energy intake and its confidence interval
Estimating changes in free-living energy intake and its confidence interval
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DOI：
10.3945/ajcn.111.014399
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发表时间：
2011-07-01
影响因子：
7.1
通讯作者：
Chow, Carson C.
中科院分区：
文献类型：
--
作者：
Hall, Kevin D.;Chow, Carson C.
背景资料：自由生活的能量摄入量在人类是出了名的难以测量，但需要适当评估门诊体重控制interventions.Objective：我们的目标是开发一种简单的方法，使用纵向体重测量来估计个体受试者的能量摄入变化及其95%CI。设计：我们展示了如何从人体代谢的任何数学模型中导出具有2个参数的能量平衡方程。我们求解了自由生活能量摄入变化的能量平衡方程，作为体重及其变化率的函数。我们测试的预测变化的能量摄入量，通过使用控制住院喂养研究的减肥数据，以及模拟自由生活的数据，从一组“虚拟研究对象”，包括现实的波动，身体水分和日常的变化，在能量intake.Results：我们的方法准确地预测个人的能量摄入量的变化与使用控制住院喂养实验的减肥数据。通过将该方法应用于我们模拟的自由生活虚拟研究受试者，我们表明，需要在>28 d的时间段内进行每日体重测量，以获得能量摄入变化的准确估计值，95% CI为
Background: Free-living energy intake in humans is notoriously difficult to measure but is required to properly assess outpatient weight-control interventions.Objective: Our objective was to develop a simple methodology that uses longitudinal body weight measurements to estimate changes in energy intake and its 95% CI in individual subjects.Design: We showed how an energy balance equation with 2 parameters can be derived from any mathematical model of human metabolism. We solved the energy balance equation for changes in free-living energy intake as a function of body weight and its rate of change. We tested the predicted changes in energy intake by using weight-loss data from controlled inpatient feeding studies as well as simulated free-living data from a group of "virtual study subjects" that included realistic fluctuations in body water and day-to-day variations in energy intake.Results: Our method accurately predicted individual energy intake changes with the use of weight-loss data from controlled inpatient feeding experiments. By applying the method to our simulated free-living virtual study subjects, we showed that daily weight measurements over periods >28 d were required to obtain accurate estimates of energy intake change with a 95% CI of