Pd-Catalyzed Spirocyclization via C-H Activation and Benzyne Insertion.
Pd-Catalyzed Spirocyclization via C-H Activation and Benzyne Insertion.
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DOI：
10.1021/acs.orglett.6b03213
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发表时间：
2016-12
期刊：
影响因子：
5.2
通讯作者：
H. Yoon;A. Lossouarn;Felicitas Landau;M. Lautens
中科院分区：
文献类型：
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作者：
H. Yoon;A. Lossouarn;Felicitas Landau;M. Lautens
钯催化的螺环化反应生成螺羟吲哚和螺二氢苯并呋喃。机理研究表明，通过连续的碳钯化，C-H活化，和苯炔插入的转化收益。这两类螺环化合物的合成产率都很高，并且该方法易于扩展。
A palladium-catalyzed spirocyclization forming spirooxindoles and spirodihydrobenzofurans has been achieved. Mechanistic studies suggest that the transformation proceeds through sequential carbopalladation, C-H activation, and benzyne insertion. Both classes of spirocycles have been synthesized in good to excellent yields, and the procedure is readily scalable.