Methapyrilene induces membrane lipid peroxidation of rat liver cells.
Methapyrilene induces membrane lipid peroxidation of rat liver cells.
复制标题
甲基吡林诱导大鼠肝细胞膜脂过氧化。
DOI：
10.1093/carcin/6.6.925
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发表时间：
1985
期刊：
影响因子：
4.7
通讯作者：
Shinozuka,H
中科院分区：
文献类型：
--
作者：
Perera,MI;Katyal,SL;Shinozuka,H
雄性Sprague Dawley大鼠饲喂基础饮食或含有0.1%盐酸甲芘林的相同饮食1、2和3天以及1和2周。通过测定二烯缀合物（紫外吸收 233 nm）形成的程度来评估肝细胞线粒体和微粒体膜脂的过氧化降解。饲喂甲基吡林 1、2 和 3 天会导致线粒体和微粒体膜发生脂质过氧化。喂养 1 周和 2 周后，从线粒体分离的脂质中过氧化不再明显，而微粒体膜脂质显示出持久的共轭二烯。结果表明，肝脏的膜脂过氧化可能在盐酸甲吡林的促进和/或致癌作用中发挥作用。
Male Sprague Dawley rats were fed either a basal diet or the same diet containing 0.1% methapyrilene hydrochloride for 1, 2 and 3 days and 1 and 2 weeks. Peroxidative degradation of membrane lipids from liver cell mitochondria and microsomes was evaluated by determining the extent of diene conjugate (u.v. absorption 233 nm) formation. Feeding methapyrilene for 1, 2 and 3 days resulted in lipid peroxida-tion of both mitochondrial and microsomal membranes. After 1 and 2 weeks feeding, peroxidation was no longer evident in lipids isolated from mitochondria, while the microsomal membrane lipids showed persistent conjugated dienes. The results suggest that membrane lipid peroxidation of the liver may play a role in the promoting and/or carcinogenic effects of methapyriline hydrochloride.