Lung epithelial progenitor cells: lessons from development.
Lung epithelial progenitor cells: lessons from development.
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DOI：
10.1513/pats.200801-006aw
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发表时间：
2008-08-15
期刊：
影响因子：
--
通讯作者：
Rawlins, Emma L
中科院分区：
文献类型：
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作者：
Rawlins, Emma L
目前对干细胞研究的热情源于这样一种希望，即有一天受损或患病的组织可能通过操纵内源性或外源性干细胞来修复。出生后的人类呼吸系统是非常容易接近的，并提供了应用这些技术的独特机会。已经在小鼠模型系统中鉴定了几种假定的成体肺上皮干细胞。然而，它们在体内促进不同谱系的能力及其控制机制仍不清楚。如果基于干细胞的疗法要在肺中取得成功，那么我们了解成体肺干细胞的正常行为以及如何调节是至关重要的。肺胚胎祖细胞比它们的成人对应物更好地定义和表征。此外，对各种发育组织的实验开始揭示胚胎祖细胞影响最终器官大小和结构的一般机制。这为肺胚胎祖细胞的研究提供了一个框架，便于实验设计和解释。研究成人肺干细胞的类似方法可能会在该领域取得快速进展。
The current enthusiasm for stem cell research stems from the hope that damaged or diseased tissues may one day be repaired through the manipulation of endogenous or exogenous stem cells. The postnatal human respiratory system is highly accessible and provides unique opportunities for the application of such techniques. Several putative adult lung epithelial stem cells have been identified in the mouse model system. However, their in vivo capabilities to contribute to different lineages, and their control mechanisms, remain unclear. If stem cell-based therapies are to be successful in the lung, it is vitally important that we understand the normal behavior of adult lung stem cells, and how this is regulated. Lung embryonic progenitor cells are much better defined and characterized than their adult counterparts. Moreover, experiments on a variety of developing tissues are beginning to uncover general mechanisms by which embryonic progenitors influence final organ size and structure. This provides a framework for the study of lung embryonic progenitor cells, facilitating experimental design and interpretation. A similar approach to investigating adult lung stem cells could produce rapid advances in the field.