Association of Depression/Anxiety Symptoms with Neck Pain: A Systematic Review and Meta-Analysis of Literature in China.
Association of Depression/Anxiety Symptoms with Neck Pain: A Systematic Review and Meta-Analysis of Literature in China.
复制标题
抑郁/焦虑症状与颈部疼痛的关联：中国文献的系统回顾和荟萃分析
DOI：
10.1155/2018/3259431
复制
发表时间：
2018
影响因子：
2.9
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Liu F;Fang T;Zhou F;Zhao M;Chen M;You J;Jin Y;Xie J;Liu Z
由于其高发病率和患病率，颈部疼痛（NP）中抑郁/焦虑症状的潜在关系尚未得到充分证明。
本研究旨在对心理问题的对照试验进行全面评估，并检验关于颈部疼痛是否在统计学上与焦虑/抑郁症状相关的假设。
对中国知网（CNKI）、维普资讯（VIP）、中国生物医学文献数据库（CBM）和万方数据（WANFANG）等中文文献数据库进行了科学检索，查找截至2018年2月5日发表的报告。纳入了包含颈部疼痛患者伴有焦虑/抑郁与健康人对比的对照试验。两名研究人员分别对每篇文章进行筛选并提取数据，且彼此对结果不知情。通过Cochrane协作网的RevMan 5.3和Stata 14.0（美国Stata公司）软件进行荟萃分析。
我们确定了13项符合条件的研究，涉及2339名患者和3290名健康人。与健康对照组相比，研究结果表明颈部疼痛患者中抑郁/焦虑症状更常见或更严重（分别为，标准化均数差[SMD]=0.89；95%置信区间[CI]=（0.58，1.20）；P<0.01以及SMD = 0.92；95%CI =（0.65，1.20）；P<0.01），汇总数据结果显示颈部疼痛患者中抑郁/焦虑症状与性别之间无统计学意义（分别为，SMD = 0.16；95%CI =（-0.18，0.51）；P = 0.35以及SMD = -0.08；95%CI =（-0.42，0.27）；P = 0.67），抑郁或焦虑症状发生率的合并数据显示颈部疼痛患者与健康人之间存在显著差异（分别为，相对危险度[RR]=4.81；95%CI =（3.30，7.01）；P<0.01以及RR = 3.29；95%CI =（2.16，5.00）；P<0.01）。此外，我们未发现符合纳入标准的文章，即比较颈部疼痛患者与其他躯体疾病在焦虑/抑郁症状方面的情况。
这项荟萃分析表明，焦虑/抑郁症状与颈部疼痛患者的高发病率相关。我们认为这些报告支持非特异性机制介导颈部疼痛中的精神障碍这一观点。本研究可能对颈部疼痛具有临床价值，为焦虑/抑郁的预防和治疗提供了一个潜在靶点。
Background Due to its high morbidity and prevalence, the potential relationships of depression/anxiety symptoms in neck pain (NP) are not well demonstrated. Objectives This study aimed to conduct a comprehensive estimation of controlled trials of psychological problems and to test hypotheses concerning whether NP was statistically relative to anxiety/depression symptoms. Methods Chinese literature databases such as the China National Knowledge Infrastructure (CNKI), VIP Information (VIP), Chinese Biomedicine (CBM), and Wanfang Data (WANFANG) were scientifically searched for reports published until February 5, 2018. Controlled trials incorporating NP patients with anxiety/depression versus healthy people were contained. Two researchers screened each article and extracted data, respectively, and blinded to the findings of each other. Meta-analysis was conducted by the Cochrane Collaboration's RevMan 5.3 and Stata 14.0 (Stata Corp LP, USA) software. Results We identified 13 eligible studies involving 2339 patients and 3290 healthy people. Compared with healthy control participants, the findings indicated that depression/anxiety symptoms were more common or severe in NP patients (respectively, SMD = 0.89; 95% CI = (0.58, 1.20); P < 0.01 and SMD = 0.92; 95% CI = (0.65, 1.20); and P < 0.01), results from the pooled data demonstrated no statistical significance between depression/anxiety symptoms and gender in NP patients (resp., SMD = 0.16; 95% CI = (−0.18, 0.51); P=0.35 and SMD = −0.08; 95% CI = (−0.42, 0.27); and P=0.67), and the combined data of the incidence of depression or anxiety symptoms revealed significant difference between NP patients and healthy persons (resp., RR = 4.81; 95% CI = (3.30, 7.01); P < 0.01 and RR = 3.29; 95% CI = (2.16, 5.00); and P < 0.01). In addition, we did not find articles that met the inclusion criteria, which compared NP patients with other physical illnesses in terms of anxiety/depression symptoms. Conclusions This meta-analysis suggests that anxiety/depression symptoms are associated with high morbidity in NP patients. We consider these reports support the viewpoint that nonspecific mechanisms mediate mental disturbances in NP. This study may have clinical value for NP, offering an underlying target for the prevention and treatment of anxiety/depression.
影响因子：
1.6
作者：
Dimitriadis, Zacharias;Kapreli, Eleni;Oldham, Jacqueline
通讯作者：
Oldham, Jacqueline
影响因子：
1.6
作者：
Altug, Filiz;Kavlak, Erdogan;Cavlak, Ugur
通讯作者：
Cavlak, Ugur