Association of Nocturia and Mortality: Results From the Third National Health and Nutrition Examination Survey
Association of Nocturia and Mortality: Results From the Third National Health and Nutrition Examination Survey
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DOI：
10.1016/j.juro.2010.09.108
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发表时间：
2011-02-01
影响因子：
6.6
通讯作者：
Rosen, Raymond C.
中科院分区：
文献类型：
--
作者：
Kupelian, Varant;Fitzgerald, Mary P.;Rosen, Raymond C.
目的：夜尿症是男性和女性的常见问题，与心脏病和高血压等慢性疾病有关。利用第三次全国健康和营养检查调查的数据，我们调查了夜尿症与随后的死亡风险之间的关系。 材料和方法：NHANES III 是美国 1988 年至 1994 年间进行的一项全国概率调查。死亡率数据是通过将 NHANES III 与国家死亡指数联系起来获得的。使用 Cox 比例风险回归模型来评估夜尿症与全因死亡率之间的关联，控制 15,988 名 20 岁或以上男性和女性样本中的潜在混杂因素。结果：夜尿症（定义为每晚排尿 2 次或以上）的患病率为 15.5%，男性为 15.5%，女性为 20.9%。多变量分析显示，男性和女性的死亡风险随着排尿次数的增加而增加，具有统计学显着趋势。 65 岁以下人群中夜尿与死亡率的关联程度更大，而 65 岁或以上年龄组中的关联程度则减弱。结论：夜尿是死亡率的强有力预测因子，在年轻男性和女性中比在老年人中更是如此，随着夜间排尿次数的增加，死亡风险增加的剂量反应模式。观察到的夜尿症与死亡风险增加之间的潜在潜在机制包括睡眠中断和相关合并症的后续发展。
Purpose: Nocturia, a common problem in men and women, has been associated with chronic illnesses such as heart disease and hypertension. Using data from the Third National Health and Nutrition Examination Survey we investigated the association of nocturia with subsequent mortality risk.Materials and Methods: NHANES III is a national probability survey of the United States between 1988 and 1994. Mortality data were obtained by linkage of NHANES III to the National Death Index. Cox proportional hazards regression models were used to assess the association between nocturia and all cause mortality, controlling for potential confounders in a sample of 15,988 men and women 20 years old or older.Results: The prevalence of nocturia, defined as 2 or more voiding episodes nightly, was 15.5% in men and 20.9% in women. Multivariate analyses showed a statistically significant trend of increased mortality risk with increased number of voiding episodes in men and women. The magnitude of the nocturia and mortality association was greater in those younger than 65 years with attenuated associations in the 65 years old or older age group.Conclusions: Nocturia is a strong predictor of mortality, more so in younger men and women than in the elderly, with a dose-response pattern in increased mortality risk with increasing number of voiding episodes nightly. Potential underlying mechanisms of the observed association of nocturia and increased mortality risk include sleep disruption and subsequent development of related comorbid conditions.