Health burden in the Netherlands due to infection with thermophilic Campylobacter spp.
Health burden in the Netherlands due to infection with thermophilic Campylobacter spp.
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DOI：
10.1017/s0950268800004933
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发表时间：
2000-12-01
影响因子：
4.2
通讯作者：
van Kempen, E
中科院分区：
文献类型：
--
作者：
Havelaar, AH;de Wit, MAS;van Kempen, E
嗜热弯曲杆菌感染。通常会导致急性胃肠炎偶尔，可能诱发更严重的疾病，特别是格林-巴利综合征和反应性关节炎。对一些人来说，这种疾病可能是致命的。我们将现有数据纳入一项公共卫生措施，即残疾调整生命年（DALY）。残疾年数是过早死亡造成的寿命损失年数和残疾寿命年数之和，疾病严重程度的加权系数在0和1之间。1990- 1995年期间荷兰人口中弯曲杆菌相关疾病的平均健康负担估计为每年1400（90% CI 900-2000）DALY。健康负担的主要决定因素是急性胃肠炎（440 DALY）、与胃肠炎相关的死亡率（310 DALY）和格林-巴利综合征的残留症状（340 DALY）。敏感性分析表明，替代模型假设产生的结果在上述范围内。
Infection with thermophilic Campylobacter spp. usually leads to an episode of acute gastroenteritis. Occasionally, more severe diseases may be induced, notably Guillain-Barre syndrome and reactive arthritis. For some, the disease may be fatal. We have integrated available data in one public health measure, the Disability Adjusted Life Year (DALY). DALYs are the sum of Years of Life Lost by premature mortality and Years Lived with Disability, weighted with a factor between 0 and 1 for the severity of illness. The mean health burden of campylobacter-associated illness in the Dutch population in the period 1990-5 is estimated as 1400 (90% CI 900-2000) DALY per year. The main determinants of health burden are acute gastroenteritis (440 DALY), gastroenteritis related mortality (310 DALY) and residual symptoms of Guillain-Barre syndrome (340 DALY). Sensitivity analysis demonstrated that alternative model assumptions produced results in the above-mentioned range.