Depth- and strain-dependent mechanical and electromechanical properties of full-thickness bovine articular cartilage in confined compression
Depth- and strain-dependent mechanical and electromechanical properties of full-thickness bovine articular cartilage in confined compression
复制标题
DOI：
10.1016/s0021-9290(00)00170-6
复制
发表时间：
2001-01-01
影响因子：
2.4
通讯作者：
Sah, RL
中科院分区：
文献类型：
--
作者：
Chen, AC;Bae, WC;Sah, RL
压缩试验经常被用来评估全层关节软骨的生物力学特性。我们测试了是否明显的均匀应变相关属性，推导出这样的测试，反映应变和深度相关的材料特性。全层牛关节软骨进行了测试，振荡限制压缩叠加在静态偏移高达45%，和数据拟合估计模量，渗透性和电动系数假设均匀。然后对部分厚度软骨进行额外测试，以评估非均匀模型中的深度和应变依赖性，假设三个离散层（i = 1，从关节面开始，i = 3，直到软骨下骨）。零应变平衡侧限压缩模量（H-A0），零应变渗透率（k（p0））和变形依赖常数（M），和变形依赖的电动力学系数（k（e））的估计不同的软骨和全层软骨的各个层。H-A0（i）从第1层增加到第3层（0.27 - 0.71MPa），并包括表观均匀值（0.47 MPa）.k（p0）（i）从第1层到第3层逐渐减小（4.6 x 10-（15）至0.50 x 10-（15）m/Pa s），小于均匀值（7.3 × 10（-15）m（2）/Pa s），而M-I从第1层增加到第3层（5.5到7.4），并变得与均匀值（8.4）相似。k（e）（i）的振幅随压缩应变显著增加，均匀值也是如此;在低应变下，在关节面附近最低，在中深层区域增加到峰值。这些结果有助于解释全层关节软骨的生物力学评估。(C)2000爱思唯尔科技有限公司版权所有。
Compression tests have often been performed to assess the biomechanical properties of full-thickness articular cartilage. We tested whether the apparent homogeneous strain-dependent properties, deduced from such tests, reflect both strain- and depth-dependent material properties. Full-thickness bovine articular cartilage was tested by oscillatory confined compression superimposed on a static offset up to 45%, and the data fit to estimate modulus, permeability, and electrokinetic coefficient assuming homogeneity. Additional tests on partial-thickness cartilage were then performed to assess depth- and strain-dependent properties in an inhomogeneous model, assuming three discrete layers (i = 1 starting from the articular surface, to i = 3 up to the subchondral bone). Estimates of the zero-strain equilibrium confined compression modulus (H-A0), the zero-strain permeability (k(p0)) and deformation dependence constant (M), and the deformation-depondent electrokinetic coefficient (k(e)) differed among individual layers of cartilage and full-thickness cartilage. H-A0(i) increased From layer 1 to 3 (0.27 to 0.71MPa), and bracketed the apparent homogeneous value (0.47 MPa).k(p0)(i) decreased from layer 1 to 3 (4.6 x 10-(15) to 0.50 x 10(-15) m/Pa s) and was less than the homogeneous value (7.3 x 10(-15) m(2)/Pa s), while M-I increased from layer 1 to 3 (5.5 to 7.4) and became similar to the homogeneous value (8.4). The amplitude of k(e)(i) increased markedly with compressive strain, as did the homogeneous value; at low strain, it was lowest near the articular surface and increased to a peak in the middle-deep region. These results help to interpret the biomechanical assessment of full-thickness articular cartilage. (C) 2000 Elsevier Science Ltd. All rights reserved.