α2-adrenoceptors and 5-HT receptors mediate the antinociceptive effect of new pyrazolines, but not of dipyrone
α2-adrenoceptors and 5-HT receptors mediate the antinociceptive effect of new pyrazolines, but not of dipyrone
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DOI：
10.1016/j.ejphar.2004.05.045
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发表时间：
2004-08-02
影响因子：
5
通讯作者：
Mello, CF
中科院分区：
文献类型：
--
作者：
Godoy, MCM;Fighera, MR;Mello, CF
在这项研究中，我们研究了脊髓去甲肾上腺素能和肾上腺素能系统是否参与了新的吡唑啉3-甲基-和3-苯基-5-羟基-5-三氯甲基-4，5-二氢-1H-1-吡唑-1-甲酰胺（MPCA和PPCA，分别），和吡唑啉酮安乃近在醋酸扭体（拉伸）小鼠实验中诱导的抗伤害性感受。鞘内（i.t.）给药麦角新碱（3和10 μ g）和育亨宾（3 μ g），但不给药哌唑嗪（0.3和1 μ g），阻止了MPCA和PPCA（500 μ mol/kg，s.c.）的抗伤害感受作用。Dipyrone诱导的抗伤害感受（500 mumol/kg，s.c.）不受麦角新碱或肾上腺素受体拮抗剂的影响。上述结果提示脊髓5-HT受体和α（2）-肾上腺素受体参与MPCA和PPCA的抗伤害作用，而不参与安乃近的抗伤害作用。(C)2004 Elsevier B. V.保留所有权利。
In this study, we investigated whether spinal noradrenergic and serotonergic systems are involved in the antinociception induced by the novel pyrazolines 3-methyl- and 3-phenyl-5-hydroxy-5-trichloromethyl-4,5-dihydro-1H-1-pyrazole-1-carboxyamide (MPCA and PPCA, respectively), and the pyrazolinone dipyrone in the acetic acid writhing (stretching) test in mice. Intrathecal (i.t.) administration of methysergide (3 and 10 mug) and yohimbine (3 mug), but not of prazosin (0.3 and I mug) prevented the antinociceptive action of MPCA and PPCA (500 mumol/kg, s.c.). Dipyrone-induced antinociception (500 mumol/kg, s.c.) was not affected by methysergide or adrenoceptor antagonists. These results suggest that spinal 5-HT receptors and alpha(2)-adrenoceptors are involved in the antinociception induced by MPCA and PPCA, but not in that elicited by dipyrone. (C) 2004 Elsevier B.V. All rights reserved.