TEMPORAL BOUNDARY OF THE SENSITIVE PERIOD FOR HORMONAL ORGANIZATION OF SOCIAL PLAY IN JUVENILE RATS
TEMPORAL BOUNDARY OF THE SENSITIVE PERIOD FOR HORMONAL ORGANIZATION OF SOCIAL PLAY IN JUVENILE RATS
复制标题
DOI：
10.1016/0031-9384(81)90017-2
复制
发表时间：
1981-01-01
影响因子：
2.9
通讯作者：
MEANEY, MJ
中科院分区：
文献类型：
--
作者：
BEATTY, WW;DODGE, AM;MEANEY, MJ
幼年大鼠的打闹是一种性别二态性行为，其受到睾酮和二氢睾酮的组织作用的影响，但不依赖于这些睾丸激素的激活影响。为了更精确地界定这些组织效应在早期发育中表达的时间段，雄性大鼠在出生后 1、6、10 或 20 天被阉割，并将它们的游戏行为与完整的雄性和雌性进行比较。对 31-40 天龄的 6-7 只动物进行每日观察。完整的雄性比雌性更频繁地进行粗暴的游戏，并且也发起了更多的游戏回合。第 10 天或第 20 天的阉割不会影响雄性的玩耍，但第 1 天或第 6 天的阉割将雄性的玩耍降低到与雌性没有可靠差异的水平。社交游戏的发展取决于出生后至少 6 天睾丸雄激素的存在。
The play-fighting of juvenile rats is a sexually dimorphic behavior which is influenced by the organizational actions of testosterone and dihydrotestosterone but is not dependent on activational influences of these testicular hormones. To delimit more precisely the temporal period in early development when these organizational effects are expressed, male rats were castrated 1, 6, 10 or 20 days after birth and their play behavior was compared to that of intact males and females. Daily observations were made of groups of 6-7 animals from 31-40 days of age. Intact males engaged in rough play more frequently than females and also initiated more play bouts. Castration at day 10 or 20 did not affect play in males, but castration on day 1 or 6 reduced male play to levels that were not reliably different from females. The development of social play depends on the presence of testicular androgens for at least 6 days after birth.