Clinical Performance of 2 Dedicated PET Scanners for Breast Imaging: Initial Evaluation
Clinical Performance of 2 Dedicated PET Scanners for Breast Imaging: Initial Evaluation
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DOI：
10.2967/jnumed.111.100958
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发表时间：
2012-10-01
影响因子：
9.3
通讯作者：
Togashi, Kaori
中科院分区：
文献类型：
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作者：
Iima, Mami;Nakamoto, Yuji;Togashi, Kaori
本研究的目的是调查2种新开发的专用乳腺PET扫描仪对已知或疑似乳腺癌患者的诊断性能。方法：评价两种类型的扫描仪，O形扫描仪和C形扫描仪。O型扫描仪设计用于俯卧的患者成像，C型扫描仪设计用于前倾的患者。69例已知或疑似乳腺癌的女性（80处病变：72例浸润性癌，4例非浸润性癌[导管原位癌或DCIS]，1例腺瘤性导管增生和3例良性病变）入组本研究。所有患者均接受常规全身PET/CT扫描，然后使用两种专用设备进行乳腺扫描。评估了每台扫描仪的诊断性能。结果如下：浸润性肿瘤最大直径4 ~ 112 mm，平均26 mm。76个恶性病灶中，62个（包括3个DC（S））被O型超声检出，5个未检出，9个病灶在视野外。76个恶性病灶中，63个病灶（包括2个DC（S））被C型超声检出，7个病灶未检出，6个病灶在视野外。O型和C型扫描仪基于病变的灵敏度分别为82%（62/76）和83%（63/76）;排除视野外病变的灵敏度分别为93%（62/67）和90%（63/70）。常规PET/CT诊断的敏感性为92%（70/76）。所有视野外病变均靠近胸壁。O型、C型和传统扫描仪的乳腺特异性分别为98%（48/49）、98%（56/57）和100%（70/70）。结论：我们的初步研究表明，这两种专用乳腺PET扫描仪在临床上是可行的，并产生合理的高灵敏度。与传统扫描仪相比，这些扫描仪获得了更详细的信息。
The purpose of this study was to investigate the diagnostic performance of 2 newly developed dedicated breast PET scanners in patients with known or suspected breast cancer. Methods: Two types of scanner were evaluated, an O-shaped scanner and a C-shaped scanner. The O scanner was designed for imaging patients who were prone, and the C scanner was designed for those patients positioned leaning forward. Sixty-nine women with known or suspected breast carcinoma (80 lesions: 72 invasive carcinomas, 4 noninvasive carcinomas [ductal carcinoma in situ, or DCIS], 1 case of adenomatous ductal hyperplasia, and 3 benign lesions) were enrolled in this study. All patients underwent a conventional whole-body PET/CT scan, followed by breast scanning using both dedicated devices. The diagnostic performance of each scanner was assessed. Results: The maximal diameter of invasive tumors ranged from 4 to 112 mm, with an average of 26 mm. With the O scanner, 62 of 76 malignant lesions (including 3 DC(S) were detected, 5 lesions were not detected, and the remaining 9 lesions were outside the field of view. With the C scanner, 63 of 76 malignant lesions (including 2 DC(S) were detected, 7 lesions were not detected, and the remaining 6 lesions were outside the field of view. The lesion-based sensitivities of the O and C scanners were 82% (62/76) and 83% (63/76), respectively; sensitivities excluding lesions outside the field of view were 93% (62/67) and 90% (63/70), respectively. The sensitivity of conventional PET/CT was 92% (70/76). All lesions outside the field of view were close to the chest wall. The breast-based specificities of the O, C, and conventional scanners were 98% (48/49), 98% (56/57), and 100% (70/70), respectively. Conclusion: Our preliminary study indicates that both dedicated breast PET scanners are clinically feasible and yield reasonably high sensitivity. More detailed information was obtained with these scanners than with the conventional scanner.