Visible-Light-Mediated Anti-Regioselective Nitrone 1,3-Dipolar Cycloaddition Reaction and Synthesis of Bisindolylmethanes
Visible-Light-Mediated Anti-Regioselective Nitrone 1,3-Dipolar Cycloaddition Reaction and Synthesis of Bisindolylmethanes
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可见光介导的反区域选择性硝酮1,3-偶极环加成反应及双吲哚基甲烷的合成
DOI：
10.1021/acs.orglett.7b02251
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发表时间：
2017
期刊：
影响因子：
5.2
通讯作者：
Xia Wujiong
中科院分区：
文献类型：
--
作者：
Zheng Lewei;Gao Fei;Yang Chao;Gao Guo-Lin;Zhao Yating;Gao Yuan;Xia Wujiong
报道了硝酮与烯烃的 1,3-偶极环加成光氧化还原反应的进展。它提供了一种在温和条件下以合成有用收率获得异恶唑烷衍生物的有效合成方法。硝酮与可氧化苯乙烯和脂肪族烯烃通过极性自由基交叉环加成反应通过光催化反应进行环化，无需添加剂。此外，该方法还可以制备双(吲哚)甲烷。
The development of photoredox reactions of 1,3-dipolar cycloaddition of nitrones with alkenes is reported. It offers an efficient synthetic method to obtain isoxazolidine derivatives under mild conditions in synthetically useful yields. The nitrones are cyclized with oxidizable styrenes and aliphatic alkenes via a polar radical crossover cycloaddition reaction through photocatalytic reaction without additives. In addition, bis(indole)methanes can also be prepared through this method.