Failure of periconceptual folic acid to prevent a neural tube defect in the offspring of a mother taking sodium valproate
Failure of periconceptual folic acid to prevent a neural tube defect in the offspring of a mother taking sodium valproate
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DOI：
10.1053/seiz.1999.0283
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发表时间：
1999-06-01
影响因子：
3
通讯作者：
Patterson, V
中科院分区：
文献类型：
--
作者：
Craig, J;Morrison, P;Patterson, V
服用丙戊酸钠(VPA)的妇女生下患有神经管缺陷(NTD)的婴儿的风险约为2%1，至少是英国本底风险的60倍。由于这类似于以前生过患有这种疾病的婴儿的NTD复发的情况，对他们来说，大剂量的围产期叶酸(4毫克/天)已知可以提供相当大的保护2，因此有人建议服用VPA的妇女应该在产后服用类似的高剂量围产期。我们报告了一名暴露于VPA的妇女，尽管她在妊娠期间服用了高剂量的叶酸，但仍生下了一名患有NTD和其他畸形的婴儿，并强调没有证据表明任何剂量的叶酸可以预防VPA引起的NTDS。
The risk of having a baby with a neural tube defect (NTD) for women taking sodium valproate (VPA) is about 2% 1, or at least 60 times the background risk in the UK. Since this is similar to that for recurrence of a NTD in someone who has previously had a baby with this condition, for whom high-dose periconceptual folic acid (4 mgs/day) is known to offer considerable protection2, it has been suggested that women on VPA should take a similar high-dose periconceptually. We report the case of a woman exposed to VPA who gave birth to an infant with an NTD, among other malformations, despite taking high-dose folic acid periconceptually and emphasize there is no evidence that folic acid in any dose protects against NTDs caused by VPA.