Computational Simulations of the Early Steps of Protein Aggregation
Computational Simulations of the Early Steps of Protein Aggregation
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DOI：
10.4161/pri.1.1.3969
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发表时间：
2007-01
期刊：
影响因子：
2.3
通讯作者：
Guanghong Wei;N. Mousseau;P. Derreumaux
中科院分区：
文献类型：
--
作者：
Guanghong Wei;N. Mousseau;P. Derreumaux
有强有力的证据表明，在聚集的早期阶段形成的关键蛋白质的低聚物可能是与人类神经退行性疾病（如阿尔茨海默病和朊病毒疾病）相关的主要有毒物质。在这里，我们回顾了最近的进展，在发展的计算方法，以了解低聚物的结构，动力学和自由能表面。我们还讨论了未来几年可能的研究方向。
There is strong evidence that the oligomers of key proteins, formed during the early steps of aggregation, could be the primary toxic species associated with human neurodegenerative diseases, such as Alzheimer’s and prion diseases. Here, we review recent progress in the development of computational approaches in order to understand the structures, dynamics and free energy surfaces of oligomers. We also discuss possible research directions for the coming years.