Ultrasound-enhanced drug delivery in prostate cancer xenografts by nanoparticles stabilizing microbubbles
Ultrasound-enhanced drug delivery in prostate cancer xenografts by nanoparticles stabilizing microbubbles
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DOI：
10.1016/j.jconrel.2014.05.020
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发表时间：
2014-08-10
影响因子：
10.8
通讯作者：
Davies, Catharina de lange
中科院分区：
文献类型：
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作者：
Eggen, Siv;Fagerland, Stein-Martin;Davies, Catharina de lange
由于缺乏对肿瘤组织的特异性、纳米颗粒穿过血管壁的运输有限以及对肿瘤细胞外基质的渗透性差，将纳米颗粒递送至实体瘤通常是无效的。超声波是一种有前途的工具，可以潜在地改善几个运输步骤，声波和微泡之间的相互作用产生生物效应，有利于纳米载体及其内容物的成功输送。在这项研究中，研究了一种由纳米颗粒稳定的微泡组成的新型平台，探讨其超声增强递送至肿瘤异种移植物的潜力。共焦激光扫描显微镜用于研究脉管系统中纳米颗粒的供应，并在微观水平上评估不同超声参数的影响。结果表明，尽管肿瘤内的递送是不均匀的，但当纳米颗粒与微泡和超声结合时，纳米颗粒和释放的模型药物的递送和微观分布都有显着改善。讨论了改善交付的机制。 (C) 2014 Elsevier B.V. 保留所有权利。
The delivery of nanoparticles to solid tumors is often ineffective due to the lack of specificity towards tumor tissue, limited transportation of the nanoparticles across the vascular wall and poor penetration through the extracellular matrix of the tumor. Ultrasound is a promising tool that can potentially improve several of the transportation steps, and the interaction between sound waves and microbubbles generates biological effects that can be beneficial for the successful delivery of nanocarriers and their contents. In this study, a novel platform consisting of nanoparticle-stabilized microbubbles has been investigated for its potential for ultrasound-enhanced delivery to tumor xenografts. Confocal laser scanning microscopy was used to study the supply of nanoparticles from the vasculature and to evaluate the effect of different ultrasound parameters at a microscopic level. The results demonstrated that although the delivery is heterogeneous within tumors, there is a significant improvement in the delivery and the microscopic distribution of both nanoparticles and a released model drug when the nanoparticles are combined with microbubbles and ultrasound. The mechanisms that underlie the improved delivery are discussed. (C) 2014 Elsevier B. V. All rights reserved.