Model systems to the rescue: The relationship between aging and innate immunity.
Model systems to the rescue: The relationship between aging and innate immunity.
复制标题
DOI：
10.4161/cib.3.5.12561
复制
发表时间：
2010-09-01
影响因子：
--
通讯作者：
Alper, Scott
中科院分区：
文献类型：
--
作者：
Alper, Scott
在人类中，衰老和免疫系统功能之间存在相互依存的关系，每个过程都会影响另一个过程的结果。衰老会引发免疫系统功能障碍，而免疫反应的改变反过来会影响人类的寿命。线虫和果蝇等模型生物的遗传实验已经鉴定出许多可以调节生物体寿命和免疫系统功能的基因和信号通路。重要的是，许多信号通路在包括哺乳动物在内的多个物种中表现出保守的功能，这表明对这些更简单模型的研究有一天可能为调节人类衰老和免疫力铺平道路。在这里，我们使用这些简单的模型系统回顾了我们对衰老、先天免疫以及这两个过程之间的相互作用的理解的最新进展。此外，我们还讨论了这可能告诉我们有关衰老和人类先天免疫系统的信息。
In humans, there is an interdependent relationship between aging and immune system function, with each process affecting the outcome of the other. Aging can trigger immune system dysfunction, and alterations in the immune response can in turn affect human lifespan. Genetic experiments in model organisms such as C. elegans and Drosophila have led to the identification of numerous genes and signaling pathways that can modulate organismal lifespan and immune system function. Importantly, many of these signaling pathways exhibit conserved function in multiple species, including mammals, suggesting that the research in these simpler models could one day pave the way for the modulation of aging and immunity in humans. Here, we review the recent progress in our understanding of aging, innate immunity and the interaction between these two processes using these simple model systems. Additionally, we discuss what this may tell us about aging and the innate immune system in humans.