3D bone-shape changes and their correlations with cartilage T1ρ and T2 relaxation times and patient-reported outcomes over 3-years after ACL reconstruction.
3D bone-shape changes and their correlations with cartilage T1ρ and T2 relaxation times and patient-reported outcomes over 3-years after ACL reconstruction.
复制标题
ACL 重建后 3 年内 3D 骨形状变化及其与软骨 T1α 和 T2 松弛时间以及患者报告的结果的相关性。
DOI：
10.1016/j.joca.2019.01.017
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发表时间：
2019
影响因子：
7
通讯作者：
Li,X
中科院分区：
文献类型：
--
作者：
Zhong,Q;Pedoia,V;Tanaka,M;Neumann,J;Link,TM;Ma,B;Lin,J;Li,X
目的(1) 确定前交叉韧带重建 (ACLR) 后从基线到 3 年的骨形状变化。 (2)评估从基线到ACLR术后6个月的骨形态变化、软骨基质的变化以及从基线到ACLR术后3年的患者功能和症状之间的关联。方法对30例单侧ACL损伤患者的双侧膝关节进行基线、ACLR术后6个月、1、2和3年的扫描。对 13 名对照者的双侧膝盖在基线、1 年和 3 年进行了扫描。计算每个软骨室的平均 T1ρ 和 T2 值。使用统计形状模型 (SSM) 和 3D-MRI 对骨形状进行量化。使用膝关节损伤和骨关节炎结果评分 (KOOS) 评估患者功能和症状。 结果 ACLR 术后 3 年内，股骨 2（股骨内侧髁 [MF] 形状）、股骨 6（髁间切迹宽度）、胫骨 1（胫骨平台区域）和胫骨 7（胫骨内侧坡度）观察到统计学显着变化。在几种模式下，受伤膝盖和对照膝盖之间观察到统计学上的显着差异。从基线到 6 个月的骨形状变化（Δ股骨 6、Δ股骨 8 [滑车倾斜度和 MF 高度]、Δ胫骨 1）与从基线到 ACLR 后 3 年的软骨 T1ρ 和 T2 和 KOOS 之间存在统计学显着相关性。 结论 ACLR 后发生骨形状重塑，早期骨形状变化（6 个月内）与软骨基质和软骨基质相关。 ACLR 后 3 年的患者结果。骨形状可能是一种有前途的成像生物标志物，可对创伤后骨关节炎（PTOA）高风险患者进行分层。
Purpose(1) To identify bone-shape changes from baseline to 3-years after anterior cruciate ligament reconstruction (ACLR). (2) to assess association between changes in bone-shape from baseline to 6-months and changes in cartilage matrix and patient functions and symptoms from baseline to 3-years after ACLR.MethodsBilateral knees of 30 patients with unilateral ACL injuries were scanned at baseline, 6-months, 1-, 2-, and 3-years after ACLR. Bilateral knees of 13 controls were scanned at baseline, 1- and 3-years. Mean T1ρ and T2 values of each cartilage compartment were computed. Bone shape was quantified using statistical shape modeling (SSM) and 3D-MRI. Patient functions and symptoms were evaluated using Knee Injury and Osteoarthritis Outcome Score (KOOS).ResultsStatistically significant changes were observed in Femur 2 (medial femoral condyle [MF] shape), Femur 6 (intercondylar notch width), Tibia 1 (tibia plateau area), and Tibia 7 (medial tibia slope) over 3-years after ACLR. Statistically significant differences were observed between injured and control knees in several modes. Statistically significant correlations were found between changes in bone shape (ΔFemur 6, ΔFemur 8 [trochlea inclination and MF height], ΔTibia 1) from baseline to 6-months and that of cartilage T1ρ and T2 and KOOS from baseline to 3-years after ACLR.ConclusionBone shape remodeling occurs after ACLR, and early bone shape changes (within 6 months) correlated with cartilage matrix and patient outcomes at 3-years after ACLR. Bone shape can be a promising imaging biomarker that stratifies patients at high risk for post-traumatic osteoarthritis (PTOA).