The effects of alcohol consumption on mortality and morbidity: A 26-year follow-up study
The effects of alcohol consumption on mortality and morbidity: A 26-year follow-up study
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DOI：
10.15288/jsa.2001.62.783
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发表时间：
2001-11-01
期刊：
影响因子：
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通讯作者：
Engfeldt, P
中科院分区：
文献类型：
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作者：
Theobald, H;Johansson, SE;Engfeldt, P
目的：探讨饮酒对死亡率和发病率的长期影响。方法：1969年，从瑞典斯德哥尔摩县的45万居民中随机抽取32,185人（50.5%为女性）。酒精消费数据来自邮寄问卷;回复率为87%（n = 28，001）。死亡率和发病率的数据来自国家死因登记处，癌症登记处和住院登记处1971-1996年，结果：参考组是中度消费者的酒精饮料。高消费男性的心血管疾病（相对危险比[RR] = 1.28; 95%可信区间[CI]：1.12- 1.46）、意外或中毒（RR = 2.10：CI：1.67-2.65）和胃肠道疾病（RR = 4.65; CI：2.93-7.36）死亡风险增加。高消费妇女仅因意外或中毒（RR = 2.95; CI：1.82-4.78）和胃肠道疾病（RR = 3.60; CI：1.40-9.24）而增加死亡风险。对于低消费女性，心血管疾病的死亡风险增加（RR = 1.25; CI：1.07-1.47）。低消费男性也有心血管疾病的死亡率增加（RR = 1.23; CI：1.05-1.44）。关于发病率的结果几乎反映了死亡率的结果，只有一个例外;对于低消费男性，心血管疾病的发病率没有增加。结论：与不同饮酒水平相关的死亡率和发病率与相同的疾病相关，这表明酒精可能是这些疾病的致病因素之一。在对酒精消费的负面影响的反应方面，性别之间存在差异的原因仍然不明。
Objective: To investigate the long-term effects of the consumption of alcohol on mortality and morbidity. Method: A sample of 32,185 (50.5% female) individuals was randomly selected from the 450,000 inhabitants of Stockholm County, Sweden, in 1969. Alcohol consumption data were obtained from postal questionnaires; response rate was 87% (n = 28,001). Data on mortality and morbidity were obtained from the National Cause of Death Register, the Cancer Register and the Inpatient Register 1971-1996, Results: The reference groups were moderate consumers of alcoholic beverages. High-consumption men had increased risks of mortality from cardiovascular diseases (relative risk ratio [RR] = 1.28; 95% confidence interval [Cl]: 1.12-1,46), accidents or poisoning (RR = 2.10: CI: 1.67-2.65) and gastrointestinal diseases (RR = 4.65; Cl: 2.93-7.36). High-consumption women had an increased risk of mortality only from accidents or poisoning (RR = 2.95, Cl: 1.82-4.78) and gastrointestinal diseases (RR = 3.60; Cl: 1.40-9.24). For low-consumption women, there was an increased risk of mortality from cardiovascular diseases (RR = 1.25; Cl: 1.07-1.47). Low-consumption men also had an increased mortality from cardiovascular diseases (RR = 1.23; Cl: 1.05-1.44). The results with respect to morbidity almost mirrored the results for mortality, with one exception; for low-consumption men, the morbidity from cardiovascular diseases was not increased. Conclusions: The mortality and morbidity associated with different levels of alcohol consumption are associated with the same diseases, which suggests that alcohol may be one of the causative factors for these diseases. The reasons for the differences between genders, regarding responses to the negative effects of alcohol consumption, are still unknown.