The reaction of lithium trimethylsilyldiazomethane with pyroglutamates - a facile synthesis of 6-diazo-5-oxo-norleucine and derivatives
The reaction of lithium trimethylsilyldiazomethane with pyroglutamates - a facile synthesis of 6-diazo-5-oxo-norleucine and derivatives
复制标题
DOI：
10.1016/s0040-4039(98)00402-x
复制
发表时间：
1998-05-14
影响因子：
1.8
通讯作者：
Saint, RE
中科院分区：
文献类型：
--
作者：
Coutts, IGC;Saint, RE
在-100℃以下，焦谷氨酸酯氨基甲酸酯衍生物与三甲基硅基重氮甲烷锂盐反应，得到了相应的取代6-重氮-5-氧-去甲亮氨酸酯；fmoc取代产物的裂解为母体酸提供了一条安全、方便的途径。1998爱思唯尔科学有限公司版权所有。
The reaction of carbamate derivatives of pyroglutamic acid esters with the lithium salt of trimethylsilyldiazomethane below -100 degrees C gives good yields of the corresponding substituted 6-diazo-5-oxo-norleucine esters; cleavage of Fmoc-substituted products provides a safe, convenient route to the parent acid. (C) 1998 Elsevier Science Ltd. All rights reserved.