PERITONEAL INCLUSION CYSTS WITH MURAL MESOTHELIAL PROLIFERATION - A CLINICOPATHOLOGICAL ANALYSIS OF 6 CASES
PERITONEAL INCLUSION CYSTS WITH MURAL MESOTHELIAL PROLIFERATION - A CLINICOPATHOLOGICAL ANALYSIS OF 6 CASES
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DOI：
10.1097/00000478-198612000-00003
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发表时间：
1986-12-01
影响因子：
5.6
通讯作者：
CLEMENT, PB
中科院分区：
文献类型：
--
作者：
MCFADDEN, DE;CLEMENT, PB
本文报告了6例罕见的、迄今未见报道的盆腔囊肿的临床和病理特征。这些囊肿发生在女性患者(15-51岁)，她们表现为下腹痛和盆腔肿块的证据。除一名患者外，其余患者均有骨盆手术史。剖腹手术发现致密的盆腔粘连和一个囊性病变，外科医生将其解释为卵巢起源。肉眼可见直径达15厘米的单房性或多房性薄壁囊肿，内含血性或浆液性积液。它们附着在卵巢表面，但不累及卵巢实质。镜下可见囊壁由明显炎症的肉芽组织和纤维组织组成，其内嵌有间皮细胞，排列成腺体、巢、索和单细胞。由于这种浸润性模式，以及间皮细胞内的细胞学异型性和有丝分裂活性，在几个病例中考虑了癌症的诊断。术后6个月至5年，所有患者均存活，无疾病迹象。我们认为这些囊肿是腹膜包涵体囊肿(良性囊性间皮瘤)，其组织学外观因不寻常程度的炎症、纤维化和间皮细胞被困住而改变。
The clinical and pathological features of six cases of a rare, hitherto unreported type of pelvic cyst are described. The cysts occurred in female patients (15-51 years of age) who presented with lower abdominal pain and evidence of a pelvic mass. All but one of the patients had a history of prior pelvic surgery. Laparotomy revealed dense pelvic adhesions and a cystic lesion that was interpreted by the surgeon as ovarian in origin. On gross examination, the cysts measured up to 15 cm in diameter, were uni- or multilocular and thin-walled, and contained bloody or serous fluid. They were adherent to the surface of the ovaries, but did not involve the ovarian parenchyma. On microscopic examination, the cyst walls were composed of markedly inflamed granulation and fibrous tissue in which were embedded mesothelial cells arranged in glands, nests, cords, and single cells. Because of this infiltrative pattern, as well as cytological atypia and mitotic activity within the mesothelial cells, a diagnosis of cancer was considered in several cases. All patients are alive with no evidence of disease at postoperative intervals of 6 months to 5 years. We propose that these cysts represent peritoneal inclusion cysts (benign cystic mesotheliomas) in which the histological appearance has been altered by an unusual degree of inflammation, fibrosis, and entrapment of mesothelial cells.