Developmental Twin Study of Attention Problems High Heritabilities Throughout Development
Developmental Twin Study of Attention Problems High Heritabilities Throughout Development
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DOI：
10.1001/jamapsychiatry.2013.287
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发表时间：
2013-03-01
期刊：
影响因子：
25.8
通讯作者：
Larsson, Henrik
中科院分区：
文献类型：
--
作者：
Chang, Zheng;Lichtenstein, Paul;Larsson, Henrik
内容：儿童期注意力缺陷多动障碍和成人期注意力缺陷多动障碍之间的遗传和环境联系尚不清楚，因为缺乏交叉信息者数据的纵向研究。目的：探讨遗传和环境影响对儿童期至成年早期注意力问题症状的相对影响。设计：分析采用纵向结构方程模型与多个informants.Setting：瑞典儿童和青少年发展的双胞胎研究。参与者：对1480对双胞胎从儿童期到青年期进行前瞻性随访。在8至9岁、13至14岁、16至17岁和19至20岁时，使用父母和自我评定的注意力问题量表获得症状。最佳拟合模型显示，从儿童期到成年早期，注意力问题的遗传性很高，这是由父母和自我评级所指示的（h（2）=0.77-0.82）。在8至9岁的遗传效应继续发挥作用，在13至14岁、16至17岁和19至20岁解释了41%、34%和24%的总方差。此外，新的一套遗传风险因素出现在13至14岁，16至17岁，19至20 years.Conclusions：自我和线人评定的注意力问题的共同观点是高度遗传的儿童，青少年和成年早期，这表明以前的报告注意力缺陷/多动障碍在成人中的低遗传性是最好的解释由评级器的影响。遗传稳定性和遗传创新都存在于整个发展阶段，这表明注意力问题是一个发育复杂的表型，其特征在于整个生命周期的连续性和变化。JAMA精神病学杂志2013;70（3）：311-318. 2013年1月2日在线发布。doi：10.1001/jamapsychiatry.2013.287
Context: The genetic and environmental link between attention-deficit/hyperactivity disorder in childhood and the adult manifestation of the disorder is poorly understood because of a lack of longitudinal studies with cross-informant data.Objective: To explore the relative contribution of genetic and environmental influences on symptoms of attention problems from childhood to early adulthood.Design: Analysis was conducted using longitudinal structural equation modeling with multiple informants.Setting: The Swedish Twin Study of Child and Adolescent Development.Participants: One thousand four hundred eighty twin pairs were prospectively followed up from childhood to young adulthood.Main Outcome Measures: Symptoms were obtained using parent and self-ratings of the Attention Problems Scale at ages 8 to 9, 13 to 14, 16 to 17, and 19 to 20 years.Results: The best-fitting model revealed high heritability of attention problems as indexed by parent and self-ratings from childhood to early adulthood (h(2)=0.77-0.82). Genetic effects operating at age 8 to 9 years continued, explaining 41%, 34%, and 24% of the total variance at ages 13 to 14, 16 to 17, and 19 to 20 years. Moreover, new sets of genetic risk factors emerged at ages 13 to 14, 16 to 17, and 19 to 20 years.Conclusions: The shared view of self-and informant-rated attention problems is highly heritable in childhood, adolescence, and early adulthood, suggesting that the previous reports of low heritability for attention-deficit/hyperactivity disorder in adults are best explained by rater effects. Both genetic stability and genetic innovation were present throughout this developmental stage, suggesting that attention problems are a developmentally complex phenotype characterized by both continuity and change across the life span. JAMA Psychiatry. 2013;70(3):311-318. Published online January 2, 2013. doi:10.1001/jamapsychiatry.2013.287