Physical exercise conditioning in the absence of weight loss reduces fasting and postprandial triglyceride-rich lipoprotein levels.
Physical exercise conditioning in the absence of weight loss reduces fasting and postprandial triglyceride-rich lipoprotein levels.
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在不减肥的情况下进行体育锻炼会降低空腹和餐后富含甘油三酯的脂蛋白水平。
DOI：
10.1161/01.cir.79.5.1007
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发表时间：
1989
期刊：
影响因子：
37.8
通讯作者：
Breslow,JL
中科院分区：
文献类型：
--
作者：
Weintraub,MS;Rosen,Y;Otto,R;Eisenberg,S;Breslow,JL
研究了体育锻炼对6名正常血脂受试者空腹和餐后脂蛋白水平的影响。这项研究包括两个阶段：基线稳定阶段，受试者保持有规律的体力活动；运动调节阶段，受试者在7周内进行29次锻炼。每一次训练都包括在跑步机上慢跑30分钟。受试者平均每周跑15.2英里。为了控制可能的混杂因素，如饮食结构的变化和体重减轻，我们将受试者安排在新陈代谢饮食中，并在锻炼阶段增加他们每天的卡路里摄入量。在研究的每个阶段结束时，进行维生素A脂肪负荷测试，以具体标记和跟踪餐后脂蛋白水平，并进行最大耗氧量测试，以评估受试者的身体健康。运动调理阶段显著提高受试者有氧能力和肝素脂蛋白脂酶活性，降低空腹甘油三酯水平。体育锻炼还显著降低了乳胶粒(SF大于1,000)水平37%。综上所述，这项研究表明，体育锻炼通过增加富含甘油三酯的颗粒的分解代谢来降低空腹和餐后脂蛋白水平。因为这些颗粒可能在动脉粥样硬化形成中起作用，这可能是运动预防冠心病的一个主要机制。
The effect of physical exercise conditioning on fasting and postprandial lipoprotein levels was studied in six normolipidemic subjects. The study consisted of two phases: a baseline stabilization phase in which subjects maintained their regular physical activity and an exercise conditioning phase in which subjects had 29 exercise sessions during a 7-week period. Each of these sessions consisted of jogging on a treadmill for 30 minutes. The subjects averaged 15.2 miles/wk. To control for possible confounding factors, such as changes in diet composition and weight loss, we placed the subjects on a metabolic diet and increased their daily caloric intake during the exercise phase. At the end of each phase of the study, a vitamin A-fat loading test was done to specifically label and follow postprandial lipoprotein levels, and a maximum oxygen consumption test was done to evaluate the subjects' physical fitness. The exercise conditioning phase significantly increased the subjects' aerobic capacity and postheparin lipoprotein lipase activity, and the phase decreased fasting triglyceride levels. Physical exercise also significantly decreased chylomicron (Sf greater than 1,000) levels by 37%. In summary, this study suggests that physical exercise conditioning reduces fasting and postprandial lipoprotein levels by increasing the catabolism of triglyceride-rich particles. Because these particles may have a role in atherogenesis, this could be a major mechanism by which exercise prevents coronary heart disease.