Conservation and evolutionary dynamics of the agr cell-to-cell communication system across firmicutes
Conservation and evolutionary dynamics of the agr cell-to-cell communication system across firmicutes
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DOI：
10.1128/jb.01135-07
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发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Babu, M. Madan
中科院分区：
文献类型：
--
作者：
Wuster, Arthur;Babu, M. Madan
我们提出的证据表明，AGR细胞间的通讯系统存在于包括人类病原体产气荚膜梭菌在内的多个细菌中。虽然我们发现AGR系统在进化上是保守的，而且它在不同物种中调控的一般功能是相似的，但单个调控基因并不相同。这表明，由AGR控制的监管网络是动态的，并迅速演变。
We present evidence that the agr cell-to-cell communication system is present across firmicutes, including the human pathogen Clostridium perfringens. Although we find that the agr system is evolutionarily conserved and that the general functions which it regulates are similar in different species, the individual regulated genes are not the same. This suggests that the regulatory network controlled by agr is dynamic and evolves rapidly.