Knee osteoarthritis, knee joint pain and aging in relation to increasing serum hyaluronan level in the Japanese population
Knee osteoarthritis, knee joint pain and aging in relation to increasing serum hyaluronan level in the Japanese population
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DOI：
10.1016/j.joca.2010.10.021
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发表时间：
2011-01-01
影响因子：
7
通讯作者：
Toh, S.
中科院分区：
文献类型：
--
作者：
Inoue, R.;Ishibashi, Y.;Toh, S.
目的：探讨日本人群血清透明质酸(HA)水平与膝关节骨关节炎(OA)的发生率、严重程度及膝关节疼痛程度的关系。设计：共616名志愿者参与本研究。根据Kellgren-Lawrence(K-L)分级，将患者分为三组：正常(K-L 0级或1级)、中度(2级)和重度(3级或4级)。膝关节疼痛程度通过视觉模拟评分(VAS)和膝关节损伤及骨关节炎结果评分(KOOS)进行量化。比较正常组、中重度组和重度组的血清HA水平，并在调整年龄、性别和体重指数(BMI)后分析血清HA水平与膝关节骨性关节炎严重程度的关系。结果：在血清HA水平与膝关节骨性关节炎严重程度的关系上，中、重度组血清HA水平显著高于正常组(P<；0.001)。此外，在调整了年龄、性别和体重指数后，血清HA水平与膝骨性关节炎的严重程度相关(r=0.289，P<；0.001)。在正常组和中度组中，血清HA水平与膝关节疼痛和/或Koos疼痛的VAS相关。结论：血清HA水平可能有助于膝骨性关节炎的存在和严重程度的诊断。(C)2010年国际骨性关节炎研究会。爱思唯尔有限公司出版。保留所有权利。
Objective: To investigate relationship between serum hyaluronan (HA) level and the presence and severity of radiographic knee osteoarthritis (OA) as well as degree of knee pain in Japanese population.Design: A total of 616 volunteers participated in this study. Based on the Kellgren-Lawrence (K-L) grade, participants were radiographically classified into three groups: Normal (K-L grade 0 or 1), Moderate (grade 2) and Severe (grade 3 or 4). The degree of knee pain was quantified by visual analogue scale (VAS) and Knee injury and Osteoarthritis Outcome Score (KOOS) Pain. Serum HA levels were compared among the Normal, Moderate and Severe groups, and the relationship between serum HA level and the severity of knee OA was analyzed after age, sex and body mass index (BMI) were adjusted. In addition, the correlation between serum HA level and the degree of knee pain was analyzed in each group.Results: Regarding relationship between serum HA level and the severity of radiographic knee OA, serum HA levels of the Moderate and Severe groups were significantly higher than in the Normal group (P < 0.001). Furthermore, serum HA level correlated with the severity of radiographic knee OA (r = 0.289, P < 0.001) after adjusting for age, sex and BMI. Serum HA level correlated with VAS of knee pain and/or KOOS Pain in the Normal and Moderate groups.Conclusion: Serum HA level has the potential to be useful for the diagnosis of the presence and severity of knee OA. (C) 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.