Transport mechanism of a glutamate transporter homologue GltPh.
Transport mechanism of a glutamate transporter homologue GltPh.
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DOI：
10.1042/bst20160055
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发表时间：
2016-06-15
影响因子：
3.9
通讯作者：
Goldman A
中科院分区：
文献类型：
--
作者：
Ji Y;Postis VL;Wang Y;Bartlam M;Goldman A
谷氨酸转运体负责摄取哺乳动物中枢神经系统中的神经递质谷氨酸。它们的古生菌同源物GltPh是从霍氏热球菌中分离出来的一种天冬氨酸转运蛋白，通过结晶学、MD模拟和单分子FRET(SmFRET)一直是广泛研究的焦点。在此，我们对GltPh的最新研究进展进行综述，以期对这种天冬氨酸转运蛋白的转运机制有所了解。
Glutamate transporters are responsible for uptake of the neurotransmitter glutamate in mammalian central nervous systems. Their archaeal homologue GltPh, an aspartate transporter isolated from Pyrococcus horikoshii, has been the focus of extensive studies through crystallography, MD simulations and single-molecule FRET (smFRET). Here, we summarize the recent research progress on GltPh, in the hope of gaining some insights into the transport mechanism of this aspartate transporter.